Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Dissertation
Étude comparative des effets moléculaires et cellulaires induits par des rayonnements X de différentes énergies
TL;DR: In this article, the authors define conditions d'irradiation en termes d'energies initiales des photons, mais surtout en terms of spectres d"energie des electrons secondaires au niveau du volume cellulaire, en utilisant des simulations de Monte Carlo.
Book ChapterDOI
Epigenetics of Brain Disorders
TL;DR: In this paper , the authors describe epigenetic processes in the brain ranging from DNA and histone modifications to non-coding RNA, which are essential for the development and maintenance of neuronal networks, and for higher-order brain processes such as cognitive functions and behavior.
Book ChapterDOI
Role of Epigenetics in Age-Related Long-Term Memory Loss
TL;DR: The loss of maintenance of the epigenome is believed to be key to understanding the role of epigenetics in age-related cognitive diseases, such as AD.
Book ChapterDOI
Biological Basis of Behaviour
TL;DR: The strengths and weaknesses of a range of methodologies used for imaging the brain are reviewed, with particular attention given to the roles played by Electroencephalography, Positron Emission Tomography and functional Magnetic Resonance Imaging in the study of operational brains.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.