Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Genome-wide DNA methylation analyses in the brain reveal four differentially methylated regions between humans and non-human primates
TL;DR: The results suggest that the patterns of DNA methylation in the brain are in general similar between humans and non-human primates, and only a few differentially methylated regions (DMRs) were identified.
Journal ArticleDOI
Treadmill exercise induces selective changes in hippocampal histone acetylation during the aging process in rats
Louisiana Carolina Ferreira de Meireles,Karine Bertoldi,Laura Reck Cechinel,Bruna Schallenberger,Vanessa Kappel da Silva,Nadja Schröder,Ionara Rodrigues Siqueira +6 more
TL;DR: The data suggest that treadmill exercise can impact hippocampal the histone acetylation profile in an age- and lysine-dependent manner, and higher hippocampal H4K12 acetylations levels at both ages may be related to improvement of aversive memory performance.
Posted Content
A Validation Study of Transgenerational Effects of Childhood Conditions on the Third Generation Offspring's Economic and Health Outcomes Potentially Driven by Epigenetic Imprinting
TL;DR: In this article, the authors examined the extent to which pre-puberty nutritional conditions in one generation affect productivity-related outcomes in later generations and provided an external validation by analyzing the impact of the German famine of 1916-1918 on children and grandchildren of those exposed to the famine at ages 8-12.
Journal ArticleDOI
Understanding the physical basis of memory: Molecular mechanisms of the engram
TL;DR: The most widely held theory is that an engram is formed by a group of neurons that are active during learning, which undergoes biochemical and physical changes to store information in a stable state, and that are later reactivated during recall of the memory as mentioned in this paper .
Journal ArticleDOI
Selective Attention: A Comparative Study on Argentine Students from Different Socioeconomic Contexts.
TL;DR: Ison, Mirta Susana as discussed by the authors, M. Facultad de Psicologia; Argentina. Centro Cientifico Tecnologico Conicet - Mendoza.
References
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A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
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Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
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Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
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DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.