Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Socioeconomic status and the developing brain
TL;DR: These studies indicate that SES is an important predictor of neurocognitive performance, particularly of language and executive function, and that S ES differences are found in neural processing even when performance levels are equal.
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Lasting epigenetic influence of early-life adversity on the BDNF gene.
TL;DR: An epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect is highlighted.
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Transcription Factors in Long-Term Memory and Synaptic Plasticity
TL;DR: The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.
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Histone acetylation: molecular mnemonics on the chromatin
TL;DR: As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
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Finding the engram.
TL;DR: This Review develops four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram, and proposes that findings from 'capture' studies represent considerable progress in allowing us to observe, erase and express the engrams.
References
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Journal ArticleDOI
Inducible molecular switches for the study of long-term potentiation.
Gaël Hedou,Isabelle M. Mansuy +1 more
TL;DR: Technical and conceptual advances in unravelling the molecular bases of long-term potentiation (LTP), learning and memory using genetic approaches are reviewed, with a focus on studies aimed at testing a model suggesting that protein kinases and protein phosphatases balance each other to control synaptic strength and plasticity.
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Histone phosphorylation: how to proceed
Romain Loury,Paolo Sassone-Corsi +1 more
TL;DR: A number of experimental methodologies that are essential for the study of histone phosphorylation are described, important as identification of the signaling transduction routes leading to chromatin remodeling is critical to an understanding of all cellular processes.
Journal ArticleDOI
Addendum: Germline epimutation of MLH1 in individuals with multiple cancers
TL;DR: To determine whether the MLH1 methylation detected was, in fact, due to residual somatically derived DNA, the original spermatozoa sample was reassessed using two methodologies, but this time, methylation analysis of the imprinted control gene SNRPN, which is unmethylated in spermatoozoa cells1.