Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Journal ArticleDOI
Epigenetic Mechanisms Involved in the Effects of Maternal Hyperhomocysteinemia on the Functional State of Placenta and Nervous System Plasticity in the Offspring
Book ChapterDOI
Seasonal Allergic Rhinitis and Systems Biology-Oriented Biomarker Discovery
TL;DR: Three systems biology-oriented immunological pattern variables (biomarkers) were developed that demonstrated larger CV correct values than the separate cytokines with regard to the classification of cytokine samples in baseline (before treatment) and post-baseline (after treatment).
Journal ArticleDOI
DNA methylation epi-signature and biological age in attention deficit hyperactivity disorder patients
Gleyson F.S. Carvalho,Thaís Virgínia Moura Machado Costa,Amom M. Nascimento,Beatriz Martins Wolff,Vanessa Almeida,Y. G. Oliveira,Claudia Berlim de Mello,Mauro Muszkat,Leslie Domenici Kulikowski +8 more
TL;DR: In this paper , Wu et al. identify epi-signatures biomarkers in 29 children clinically diagnosed with ADHD and identify a marginal association between the DNAmAge and ADHD.
Book ChapterDOI
The Mind and its Nucleosomes – Chromatin (dys)Regulation in Major Psychiatric Disease
TL;DR: How recent advances in epigenome explorations of normal and diseased human brain, together with new findings in animal models, advance knowledge about molecular and cellular mechanisms of disease, with important implications for the design of novel therapies with chromatin modifying drugs is discussed.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.