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Journal ArticleDOI

Epigenetic codes in cognition and behaviour.

TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.
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This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.

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Citations
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Book ChapterDOI

Seasonal Allergic Rhinitis and Systems Biology-Oriented Biomarker Discovery

TL;DR: Three systems biology-oriented immunological pattern variables (biomarkers) were developed that demonstrated larger CV correct values than the separate cytokines with regard to the classification of cytokine samples in baseline (before treatment) and post-baseline (after treatment).
Journal ArticleDOI

DNA methylation epi-signature and biological age in attention deficit hyperactivity disorder patients

TL;DR: In this paper , Wu et al. identify epi-signatures biomarkers in 29 children clinically diagnosed with ADHD and identify a marginal association between the DNAmAge and ADHD.
Book ChapterDOI

The Mind and its Nucleosomes – Chromatin (dys)Regulation in Major Psychiatric Disease

TL;DR: How recent advances in epigenome explorations of normal and diseased human brain, together with new findings in animal models, advance knowledge about molecular and cellular mechanisms of disease, with important implications for the design of novel therapies with chromatin modifying drugs is discussed.
References
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Journal ArticleDOI

A synaptic model of memory: long-term potentiation in the hippocampus

TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI

Chromatin Modifications and Their Function

TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI

Translating the Histone Code

TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI

DNA methylation patterns and epigenetic memory

TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
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