Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Epigenetic effects of fetal alcohol exposure on hypothalamic proopiomelanocortin gene
TL;DR: The aim of the study is to contribute towards the humanizing of science by promoting an awareness of its importance in the development of scientific knowledge.
Dissertation
Epigenetska osnova velikog depresivnog poremećaja
TL;DR: Veliki depresivni poremecaj (eng. Major Depressive Disorder; MDD) jedan je od najcescih psihosomatskih porationecaja koji pokazuje izraženu tendenc.
Journal ArticleDOI
Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory
TL;DR: Recent insights into how the noradrenergic recruitment of epigenetic modifications, including DNA methylation and post-translational modification of histones, contribute to homo- and heterosynaptic plasticity are focused on.
Book ChapterDOI
Differential Expression of Long Noncoding RNA in the Rat Brain During Aging
Sukhleen Kour,Pramod C. Rath +1 more
TL;DR: The study showed the possible interrelationship between lincRNAs and various brain functions during aging, which may provide an alternative basis to study various age-related neurological diseases and disorders.
Les empreintes des drogues sur le génome: avancées récentes
TL;DR: L'impact des substances a risque d'abus sur le cerveau au niveau moleculaire and cellulaire a ete tres etudie chez les rongeurs and chez l'homme and reflexion sur leur importance possible dans the prise en charge des toxicomanes.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.