Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
Reads0
Chats0
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
More filters
Journal ArticleDOI
DNA methylation and memory formation
Jeremy J. Day,J. David Sweatt +1 more
TL;DR: The existing evidence supporting a role for DNA methylation in memory is evaluated, how DNA methylisation may affect genetic and neuronal function to contribute to behavior is discussed, and several future directions for the emerging subfield of neuroepigenetics are proposed.
Journal ArticleDOI
Noncoding RNA in development
Paulo P. Amaral,John S. Mattick +1 more
TL;DR: Non-protein coding sequences increasingly dominate the genomes of multicellular organisms as their complexity increases, in contrast to protein-coding genes, which remain relatively static as mentioned in this paper, and there is mounting evidence that much of this transcription is involved in the regulation of differentiation and development.
Journal ArticleDOI
Long non-coding RNAs in nervous system function and disease.
TL;DR: In this paper, the authors reviewed emerging evidence that highlights the expression and function of long non-protein-coding RNAs in the central nervous system and suggests that lncRNA deregulation is an important factor in various CNS pathologies including neurodevelopmental, neurodegenerative and neuroimmunological disorders, primary brain tumors, and psychiatric diseases.
Journal ArticleDOI
Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes
TL;DR: The brain contains an epigenetic "hotspot" with a unique potential to not only better understand its most complex functions, but also to treat its most vicious diseases.
Journal ArticleDOI
Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases.
TL;DR: A systematic and comprehensive summary of the existing knowledge of lncRNAs is given in order to provide a better understanding of this new studying field and highlight recent studies related lnc RNAs in central nervous system development and neurodegenerative diseases.
References
More filters
Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.