Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Journal ArticleDOI
Introduction to the Special Section on Epigenetics.
TL;DR: The basics of epigenetics are presented in a way that is designed to make this exciting field accessible to a wide readership and a discussion of challenges and opportunities as the field of human behavioral epigenetics continue to grow.
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UHRF1 Links the Histone code and DNA Methylation to ensure Faithful Epigenetic Memory Inheritance
Christian Bronner,Guy Fuhrmann,Frédéric Chédin,Marcella Macaluso,Sirano Dhe-Paganon,Sirano Dhe-Paganon +5 more
TL;DR: The current knowledge of UHRF1 is reviewed and how this protein ensures the link between histone marks and DNA methylation is discussed, which may reveal the physiological relevance of the linkage between these layers of epigenetic marks.
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DNA methylation dynamics in plants and mammals: overview of regulation and dysregulation.
TL;DR: The regulation and dysregulation of DNA methylation in plants and mammals is discussed and the similarities and differences between mammals and plants are discussed.
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Opening up the DNA methylome of dementia
TL;DR: This review provides an in-depth summary of the current knowledge about DNA methylation in dementia, focusing exclusively on the analyses performed in human brain.
Journal ArticleDOI
Histone H3 lysine methylation in cognition and intellectual disability disorders.
TL;DR: The potential role of epigenetic mechanisms centered on the methylation of lysine residues on histone H3 in neuroplasticity and neurodevelopmental disorders associated with intellectual disability is discussed.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
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Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
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Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
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DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.