Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Socioeconomic status and the developing brain
TL;DR: These studies indicate that SES is an important predictor of neurocognitive performance, particularly of language and executive function, and that S ES differences are found in neural processing even when performance levels are equal.
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Lasting epigenetic influence of early-life adversity on the BDNF gene.
TL;DR: An epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect is highlighted.
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Transcription Factors in Long-Term Memory and Synaptic Plasticity
TL;DR: The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.
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Histone acetylation: molecular mnemonics on the chromatin
TL;DR: As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
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Finding the engram.
TL;DR: This Review develops four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram, and proposes that findings from 'capture' studies represent considerable progress in allowing us to observe, erase and express the engrams.
References
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Journal ArticleDOI
Epigenetic inheritance in evolution
Eva Jablonka,Marion J. Lamb +1 more
TL;DR: Look at the part EISs have played in the evolution of multicellularity, ontogeny, chromosome organization, and the origin of some post‐mating isolating mechanisms and show how considering the role of epigenetic inheritance can sometimes shed light on major evolutionary processes.
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Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain.
Suzanne Cassel,Delphine Carouge,Claire Gensburger,Patrick Anglard,Claude Burgun,Jean-Bernard Dietrich,Dominique Aunis,Jean Zwiller +7 more
TL;DR: The data highlight GABAergic neurons as major target cells expressing Mecp2 in response to the serotonin-elevating agents and suggest that serotonin signaling enhances gene silencing in postmitotic neurons.
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Like Father, Like Son The Relationships between Conviction Trajectories of Fathers and their Sons and Daughters
TL;DR: In this article, the authors investigated the relationship between convictions of fathers and the development of their offspring over the lifespan and found that children of convicted fathers are much more likely to be convicted themselves in comparison to those whose fathers have never been convicted.
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Increased histone acetyltransferase and lysine acetyltransferase activity and biphasic activation of the ERK/RSK cascade in insular cortex during novel taste learning.
Michael W. Swank,J. David Sweatt +1 more
TL;DR: The studies reveal an unanticipated long-lasting activation of insular cortex signal transduction cascades in novel taste learning and suggest the hypothesis that acute and long-term ERK activation and lysine–histone acetyltransferase activation may play a role in regulating gene expression in single-trial learning andlong-term memory formation.
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Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?
TL;DR: It is reported that SAM administration, in human neuroblastoma SK‐N‐SH cell cultures, downregulates PS1 gene expression and Ab production.