Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Journal ArticleDOI
Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration.
Radosveta Koldamova,Jonathan Schug,Martina I. Lefterova,Andrea A. Cronican,Nicholas F. Fitz,Faith A. Davenport,Alexis Y. Carter,Emilie L. Castranio,Iliya Lefterov +8 more
TL;DR: The results of this study suggest that EGR1 regulates the expression of genes involved in CME, vesicular transport and synaptic transmission that may be critical for AD pathogenesis.
Journal ArticleDOI
The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases.
TL;DR: The diverse roles reported for lncRNAs are described, and how they could mechanistically be involved in the development of central nervous system (CNS) and neurodegenerative diseases are discussed.
Journal ArticleDOI
Associations between cortical thickness and neurocognitive skills during childhood vary by family socioeconomic factors
TL;DR: Results indicated that associations between CT and cognitive performance did vary by SES, and links between brain structure and cognitive processes vary by family socioeconomic circumstance, suggesting that socioeconomic advantage may in some cases buffer against a neurobiological risk factor for poor performance.
Journal ArticleDOI
Age-related changes in Egr1 transcription and DNA methylation within the hippocampus.
TL;DR: An age‐related reduction in the transcription of Egr1 is shown in the dentate gyrus following spatial behavior, whereas in the area CA1, E gr1 is reduced at rest, but its transcription can be effectively driven by spatial behavior to levels equivalent to those observed in adult animals.
Book ChapterDOI
Epigenetics of Memory and Plasticity
TL;DR: The role of epigenetic processes in behavioral plasticity triggered by environmental experiences is discussed, and a particular focus is placed on learning and memory where the importance of methylation modifications in brain circuits is best understood.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
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DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.