Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Socioeconomic status and the developing brain
TL;DR: These studies indicate that SES is an important predictor of neurocognitive performance, particularly of language and executive function, and that S ES differences are found in neural processing even when performance levels are equal.
Journal ArticleDOI
Lasting epigenetic influence of early-life adversity on the BDNF gene.
TL;DR: An epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect is highlighted.
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Transcription Factors in Long-Term Memory and Synaptic Plasticity
TL;DR: The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.
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Histone acetylation: molecular mnemonics on the chromatin
TL;DR: As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
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Finding the engram.
TL;DR: This Review develops four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram, and proposes that findings from 'capture' studies represent considerable progress in allowing us to observe, erase and express the engrams.
References
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Journal ArticleDOI
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
TL;DR: It is reported that TSA and methionine treatment reversed the effect of maternal care on open-field behavior, and >900 genes stably regulated by maternal care were identified.
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Mice with Truncated MeCP2 Recapitulate Many Rett Syndrome Features and Display Hyperacetylation of Histone H3
Mona D. Shahbazian,Juan I. Young,Lisa A. Yuva-Paylor,Corinne M. Spencer,Barbara Antalffy,Jeffrey L. Noebels,Dawna L. Armstrong,Richard Paylor,Huda Y. Zoghbi +8 more
TL;DR: Although the truncated MeCP2 protein in these mice localizes normally to heterochromatic domains in vivo, histone H3 is hyperacetylated, providing evidence that the chromatin architecture is abnormal and that gene expression may be misregulated in this model of Rett syndrome.
Journal ArticleDOI
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
Arvind Kumar,Kwang H. Choi,William Renthal,Nadia M. Tsankova,David E. H. Theobald,Hoang Trang Truong,Scott J. Russo,Quincey LaPlant,Teresa S. Sasaki,Kimberly N. Whistler,Rachael L. Neve,David W. Self,Eric J. Nestler +12 more
TL;DR: It is shown that cocaine induces specific histone modifications at different gene promoters in striatum, a major neural substrate for cocaine's behavioral effects, and chromatin remodeling is an important regulatory mechanism underlying cocaine-induced neural and behavioral plasticity.
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Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration
Carlos A. Saura,Se-Young Choi,Vassilios Beglopoulos,Seema Malkani,Dawei Zhang,Dawei Zhang,B. S. Shankaranarayana Rao,Sumantra Chattarji,Raymond J. Kelleher,Eric R. Kandel,Karen Duff,Alfredo Kirkwood,Jie Shen +12 more
TL;DR: It is demonstrated that conditional double knockout mice lacking both presenilins in the postnatal forebrain exhibit impairments in hippocampal memory and synaptic plasticity and these deficits are associated with specific reductions in NMDA receptor-mediated responses and synaptic levels of NMDA receptors and alphaCaMKII.
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Histone sumoylation is associated with transcriptional repression
Yuzuru Shiio,Robert N. Eisenman +1 more
TL;DR: Evidence suggesting that histone sumoylation mediates gene silencing through recruitment of histone deacetylase and heterochromatin protein 1 is presented.