Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
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Histone Acetylation and Deacetylation
Daniel M. Fass,Melissa M. Kemp,Frederick A. Schroeder,Florence F. Wagner,Qiu Wang,Edward B. Holson +5 more
TL;DR: The acetylation and deacetylation of the N-terminal tails of histones (the core protein component of chromatin) represents an important epigenetic mechanism which affects chromatin structure and, ultimately genomic response, via gene expression.
Journal ArticleDOI
Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers.
TL;DR: Recent studies focusing on certain epigenetic readers, writers, and erasers associated with cancer development are summarized and how newly discovered natural compounds and their derivatives could interact with these targets are summarized.
Journal ArticleDOI
Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior
TL;DR: Recent advances in understanding of how epigenetic mechanisms contribute to the formation of long-term memory and drug-seeking behavior are discussed and potentially how to apply that knowledge to the extinction of memory anddrug-seekingbehavior is discussed.
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Detection of Transgenerational Spermatogenic Inheritance of Adult Male Acquired CNS Gene Expression Characteristics Using a Drosophila Systems Model
Abhay Sharma,Priyanka Singh +1 more
TL;DR: For the first time, detection of transgenerational spermatogenic inheritance of adult acquired somatic gene expression characteristic of PTZ induced gene expression phenotype acquired by adult Drosophila males is reported.
The biocognitive spectrum : biological cognition as variations on sensorimotor coordination
TL;DR: Van Duijns dissertatie is that the fylogenetische basis of biocognitie ligt in sensorimotor coordininatie: het vermogen van organismen om zich voort te bewegen and zich orienteren in hun omgeving om zo de externe factoren voor hun metabolisme te optimaliseren.
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
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Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
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DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.