Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Book ChapterDOI
A Gallery of Organic Codes
TL;DR: The discovery of the genetic code has revealed the existence of a deep parallel between protein synthesis and language, and this makes us realize that at the molecular level there is not only recursion but also arbitrariness.
Book ChapterDOI
Epigenetic Mechanisms in Learning and Memory
Jeremy J. Day,J. David Sweatt +1 more
TL;DR: This chapter discusses a theoretical framework for a role for epigenetic molecular mechanisms in learning and memory; how the marks are maintained and subsequently affect memory function at the cellular, circuit, and neural systems levels.
Journal ArticleDOI
An enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their piglets
Patricia Tatemoto,Fábio Pértille,Thiago Bernardino,Ricardo Zanella,Carlos Guerrero-Bosagna,Adroaldo J. Zanella +5 more
TL;DR: In this article , differentially methylated regions (DMRs) were investigated in these brain regions of male piglets born from sows kept in an enriched vs a barren environment.
Posted Content
A Validation Study of Transgenerational Effects of Childhood Conditions on the Third Generation Offspring's Economic and Health Outcomes Potentially Driven by Epigenetic Imprinting
TL;DR: In this paper, the authors examined the extent to which pre-puberty nutritional conditions in one generation affect productivity-related outcomes in later generations and provided an external validation by analyzing the impact of the German famine of 1916-1918 on children and grandchildren of those exposed to the famine at ages 8-12.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.