ExoCarta 2012: database of exosomal proteins, RNA and lipids
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TLDR
This work believes that this free web-based community resource will aid researchers in identifying molecular signatures (proteins/RNA/lipids) that are specific to certain tissue/cell type derived exosomes and trigger new exosomal studies.Abstract:
Exosomes are membraneous nanovesicles of endocytic origin released by most cell types from diverse organisms; they play a critical role in cell-cell communication. ExoCarta (http://www.exocarta.org) is a manually curated database of exosomal proteins, RNA and lipids. The database catalogs information from both published and unpublished exosomal studies. The mode of exosomal purification and characterization, the biophysical and molecular properties are listed in the database aiding biomedical scientists in assessing the quality of the exosomal preparation and the corresponding data obtained. Currently, ExoCarta (Version 3.1) contains information on 11,261 protein entries, 2375 mRNA entries and 764 miRNA entries that were obtained from 134 exosomal studies. In addition to the data update, as a new feature, lipids identified in exosomes are added to ExoCarta. We believe that this free web-based community resource will aid researchers in identifying molecular signatures (proteins/RNA/lipids) that are specific to certain tissue/cell type derived exosomes and trigger new exosomal studies.read more
Citations
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Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
TL;DR: Exosomes were described as vesicles of endosomal origin secreted from reticulocytes in the 1980s as discussed by the authors, and their biogenesis, their secretion, and their subsequent fate are discussed, as their functions rely on these important processes.
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Biological properties of extracellular vesicles and their physiological functions
María Yáñez-Mó,Pia Siljander,Zoraida Andreu,Apolonija Bedina Zavec,Francesc E. Borràs,Edit I. Buzás,Krisztina Buzas,Krisztina Buzas,Enriqueta Casal,Francesco Cappello,Joana Carvalho,Joana Carvalho,Eva Colas,Anabela Cordeiro da Silva,Anabela Cordeiro da Silva,Stefano Fais,Juan M. Falcón-Pérez,Irene M. Ghobrial,Bernd Giebel,Mario Gimona,Mario Gimona,Michael W. Graner,Ihsan Gursel,Mayda Gursel,Niels H. H. Heegaard,Niels H. H. Heegaard,An Hendrix,Peter Kierulf,Katsutoshi Kokubun,Maja Kosanović,Veronika Kralj-Iglič,Eva-Maria Krämer-Albers,Saara Laitinen,Cecilia Lässer,Thomas Lener,Thomas Lener,Erzsébet Ligeti,Aija Linē,Georg Lipps,Alicia Llorente,Jan Lötvall,Mateja Manček-Keber,Antonio Marcilla,María Mittelbrunn,Irina Nazarenko,Esther N. M. Nolte-‘t Hoen,Tuula A. Nyman,Lorraine O'Driscoll,Mireia Olivan,Carla Oliveira,Carla Oliveira,Éva Pállinger,Hernando A. del Portillo,Hernando A. del Portillo,Jaume Reventós,Jaume Reventós,Marina Rigau,Eva Rohde,Eva Rohde,Marei Sammar,Francisco Sánchez-Madrid,Nuno Santarém,Nuno Santarém,Katharina Schallmoser,Katharina Schallmoser,Marie Stampe Ostenfeld,Willem Stoorvogel,Roman Štukelj,Susanne G. van der Grein,M. Helena Vasconcelos,M. Helena Vasconcelos,Marca H. M. Wauben,Olivier De Wever +72 more
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other
TL;DR: The definition of exosomes and other secreted extracellular vesicles, which mediating intercellular communication between different cell types in the body, and thus affecting normal and pathological conditions are focused on.
Journal ArticleDOI
The oyster genome reveals stress adaptation and complexity of shell formation
Guofan Zhang,Xiaodong Fang,Ximing Guo,Li Li,Ruibang Luo,Fei Xu,Pengcheng Yang,Linlin Zhang,Xiaotong Wang,Haigang Qi,Zhiqiang Xiong,Huayong Que,Yinlong Xie,Peter W. H. Holland,Jordi Paps,Yabing Zhu,Fucun Wu,Yuanxin Chen,Jiafeng Wang,Chunfang Peng,Jie Meng,Lan Yang,Jun Liu,Bo Wen,Na Zhang,Zhiyong Huang,Qihui Zhu,Yue Feng,Andrew S. Mount,Dennis Hedgecock,Zhe Xu,Yunjie Liu,Tomislav Domazet-Lošo,Yishuai Du,Xiaoqing Sun,Shoudu Zhang,Binghang Liu,Peizhou Cheng,Xuanting Jiang,Juan Li,Dingding Fan,Wei Wang,Wenjing Fu,Tong Wang,Bo Wang,Jibiao Zhang,Zhiyu Peng,Yingxiang Li,Na Li,Jinpeng Wang,Maoshan Chen,Yan He,Fengji Tan,Xiaorui Song,Qiumei Zheng,Ronglian Huang,Hailong Yang,Du Xuedi,Li Chen,Mei Yang,Patrick M. Gaffney,Shan Wang,Longhai Luo,Zhicai She,Yao Ming,Huang Wen,Shu Zhang,Baoyu Huang,Yong Zhang,Tao Qu,Peixiang Ni,Guoying Miao,Junyi Wang,Qiang Wang,Christian E. W. Steinberg,Haiyan Wang,Ning Li,Lumin Qian,Guojie Zhang,Yingrui Li,Huanming Yang,Xiao Liu,Jian Wang,Ye Yin,Jun Wang +84 more
TL;DR: The sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy and transcriptomes of development and stress response and the proteome of the shell are reported, showing that shell formation in molluscs is more complex than currently understood and involves extensive participation of cells and their exosomes.
Journal ArticleDOI
RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts
Sarah Geisler,Jeff Coller +1 more
TL;DR: A paradigm in which lncRNAs regulate transcription via chromatin modulation is supported, but new functions are steadily emerging, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.
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