NIH Image to ImageJ: 25 years of image analysis
TLDR
The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.Abstract:
For the past 25 years NIH Image and ImageJ software have been pioneers as open tools for the analysis of scientific images. We discuss the origins, challenges and solutions of these two programs, and how their history can serve to advise and inform other software projects.read more
Citations
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Tau co-organizes dynamic microtubule and actin networks
Auréliane Elie,Elea Prezel,Christophe Guérin,Eric Denarier,Sacnicte Ramirez-Rios,Laurence Serre,Annie Andrieux,Anne Fourest-Lieuvin,Laurent Blanchoin,Isabelle Arnal +9 more
TL;DR: Tau, a neuronal microtubule-associated protein, binds to microtubules and actin simultaneously, promoting in vitro co-organization and coupled growth of both networks, enabling a coordination of the two cytoskeletons that might be essential in various neuronal contexts.
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Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3
Judith Houtman,Kiara Freitag,Kiara Freitag,Niclas Gimber,Jan Schmoranzer,Frank L. Heppner,Frank L. Heppner,Marina Jendrach +7 more
TL;DR: The notion that selective autophagy can impact microglia activation by modulating IL‐1beta and IL‐18 production via NLRP3 degradation is supported and the mechanism how impaired autophagic could contribute to neuroinflammation in Alzheimer's disease is presented.
Journal ArticleDOI
Central cell-derived peptides regulate early embryo patterning in flowering plants.
Liliana M. Costa,Eleanor Marshall,Mesfin Tesfaye,Kevin A. T. Silverstein,Masashi Mori,Yoshitaka Umetsu,Sophie L. Otterbach,Ranjith K Papareddy,Hugh G. Dickinson,Kim Boutiller,Kathryn A. VandenBosch,Shinya Ohki,José F. Gutierrez-Marcos +12 more
TL;DR: It is demonstrated that the second female gamete and its sexually derived endosperm regulate early embryonic patterning in flowering plants and synergistically with the receptor-like kinase SHORT SUSPENSOR to promote suspensor elongation through the YODA mitogen-activated protein kinase pathway.
Journal ArticleDOI
Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.
TL;DR: Structural observations and functional analysis of the S530T/G533V double mutant suggest a working hypothesis for the generation of 15R-HETE by aspirin-acetylated COX-2, indicating that detergent and lipid binding within the membrane-binding domain of the enzyme alters the rate of the acetylation reaction in vitro.
Journal ArticleDOI
Novel high-strength, low-alloys Zn-Mg (< 0.1 wt% Mg) and their arterial biodegradation
Hualan Jin,Shan Zhao,Roger J. Guillory,Patrick K. Bowen,Zhiyong Yin,Adam J. Griebel,Jeremy E. Schaffer,Elisha J. Earley,Jeremy Goldman,Jaroslaw Drelich +9 more
TL;DR: Zn-08Mg alloy appears to be the first formulated biodegradable material that satisfies benchmark values desirable for endovascular stenting, but the alloy reveals signs of age hardening and strain rate sensitivity, which need to be addressed before using this metal for stenting.
References
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Johannes Schindelin,Ignacio Arganda-Carreras,Erwin Frise,Verena Kaynig,Mark Longair,Tobias Pietzsch,Stephan Preibisch,Curtis Rueden,Stephan Saalfeld,Benjamin Schmid,Jean-Yves Tinevez,Daniel J. White,Volker Hartenstein,Kevin W. Eliceiri,Pavel Tomancak,Albert Cardona +15 more
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