NIH Image to ImageJ: 25 years of image analysis
TLDR
The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.Abstract:
For the past 25 years NIH Image and ImageJ software have been pioneers as open tools for the analysis of scientific images. We discuss the origins, challenges and solutions of these two programs, and how their history can serve to advise and inform other software projects.read more
Citations
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Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
Neil Vasan,Neil Vasan,Pedram Razavi,Jared L. Johnson,Hong Shao,Hardik Shah,Alesia Antoine,Erik Ladewig,Alexander N. Gorelick,Ting-Yu Lin,Eneda Toska,Guotai Xu,Abiha Kazmi,Matthew T. Chang,Barry S. Taylor,Maura N. Dickler,Maura N. Dickler,Komal Jhaveri,Sarat Chandarlapaty,Raul Rabadan,Ed Reznik,Melissa Smith,Robert Sebra,Frauke Schimmoller,Timothy R. Wilson,Lori Friedman,Lewis C. Cantley,Maurizio Scaltriti,José Baselga +28 more
TL;DR: Preliminary analysis of clinical trial data suggests that breast cancers with double mutations are more responsive to PI3K inhibitors than those with a single mutation, and PIK3CA mutational status could help identify the breast cancer patients most likely to benefit from these drugs.
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Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes.
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