NIH Image to ImageJ: 25 years of image analysis
TLDR
The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.Abstract:
For the past 25 years NIH Image and ImageJ software have been pioneers as open tools for the analysis of scientific images. We discuss the origins, challenges and solutions of these two programs, and how their history can serve to advise and inform other software projects.read more
Citations
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Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1
Hironari Nishizawa,Mitsuyo Matsumoto,Tomohiko Shindo,Daisuke Saigusa,Hiroki Kato,Katsushi Suzuki,Masaki Sato,Yusho Ishii,Hiroaki Shimokawa,Kazuhiko Igarashi +9 more
TL;DR: It is proposed that BACH1 controls the threshold of ferroPTosis induction and may represent a therapeutic target for alleviating ferroptosis-related diseases, including myocardial infarction.
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Core 1– and 3–derived O -glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice
Kirk Bergstrom,Jianxin Fu,Jianxin Fu,Malin E. V. Johansson,Xiaowei Liu,Nan Gao,Q Wu,Q Wu,Jianhua Song,J M McDaniel,Samuel McGee,Weichang Chen,Jonathan Braun,Gunnar C. Hansson,Lijun Xia,Lijun Xia,Lijun Xia +16 more
TL;DR: It is indicated that core 1– and 3–derived O-glycans collectively contribute to the mucus barrier by protecting it from bacterial protease degradation and suggests new therapeutic targets to promote mucus Barrier function in colitis patients.
Journal ArticleDOI
Mutualistic root endophytism is not associated with the reduction of saprotrophic traits and requires a noncompromised plant innate immunity
Urs Lahrmann,Nadine Strehmel,Gregor Langen,Henning Frerigmann,Lisa Leson,Yi Ding,Dierk Scheel,Siska Herklotz,Magdalena Hilbert,Alga Zuccaro,Alga Zuccaro +10 more
TL;DR: The importance of the indolic glucosinolate pathway in the growth restriction of P. indica and S. vermifera is demonstrated andIndole-phytoalexins and specifically indole-carboxylic acids derivatives are identified as potential key players in the maintenance of a mutualistic interaction with root endophytes.
Journal ArticleDOI
Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics.
Rachael D. Brust,Andrea E. Corcoran,George B. Richerson,George B. Richerson,Eugene E. Nattie,Susan M. Dymecki +5 more
TL;DR: Findings show that serotonergic regulation of the respiratory chemoreflex is mediated by a specialized molecular subtype of 5HT neuron harboring unique physiological, biophysical, and hodological properties specified developmentally and demonstrate that the serotonergy system contains specialized modules contributing to its collective functional breadth.
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Ultra-selective looming detection from radial motion opponency
Nathan C. Klapoetke,Aljoscha Nern,Martin Y. Peek,Edward M. Rogers,Patrick Breads,Gerald M. Rubin,Michael B. Reiser,Gwyneth M Card +7 more
TL;DR: The discovery of an ultra-selective looming detecting neuron, lobula plate/lobula columnar, type II (LPLC2) in Drosophila is reported, and its selectivity is established by radial motion opponency.
References
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