NIH Image to ImageJ: 25 years of image analysis
TLDR
The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.Abstract:
For the past 25 years NIH Image and ImageJ software have been pioneers as open tools for the analysis of scientific images. We discuss the origins, challenges and solutions of these two programs, and how their history can serve to advise and inform other software projects.read more
Citations
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Phase transitions of multivalent proteins can promote clustering of membrane receptors
Sudeep Banjade,Michael K. Rosen +1 more
TL;DR: Biochemical reconstitution on supported lipid bilayers of protein clusters containing the adhesion receptor Nephrin and its cytoplasmic partners, Nck and N-WASP is reported, suggesting that clustering of regulatory factors could promote local actin assembly at membranes.
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Polysulfides Link H2S to Protein Thiol Oxidation
Romy Greiner,Zoltán Pálinkás,Katrin Bäsell,Dörte Becher,Haike Antelmann,Péter Nagy,Tobias P. Dick +6 more
TL;DR: This study suggests that the effects that have been attributed to H2S in previous reports may in fact have been mediated by polysulfides, and supports the notion that sulfane sulfur rather than sulfide is the actual in vivo agent of H 2S signaling.
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Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
Jennifer L. Guerriero,Alaba Sotayo,Holly Ponichtera,Jessica A. Castrillon,Alexandra Pourzia,Sara Schad,Shawn F. Johnson,Ruben D. Carrasco,Suzan Lazo,Roderick T. Bronson,Scott Davis,Mercedes Lobera,Michael A. Nolan,Anthony Letai +13 more
TL;DR: It is demonstrated that in vivo TMP195 treatment alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes, and introduces class IIa HDAC inhibition as a means to harness the anti-tumour potential of macrophages to enhance cancer therapy.
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Room-temperature electrical control of exciton flux in a van der Waals heterostructure.
TL;DR: The ability to manipulate exciton dynamics by creating electrically reconfigurable confining and repulsive potentials for the exciton flux is demonstrated and the results make a strong case for integrating two-dimensional materials in future excitonic devices to enable operation at room temperature.
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3D printing of porous hydroxyapatite scaffolds intended for use in bone tissue engineering applications
TL;DR: Characterisation techniques utilised in this study include two funnel flow tests, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), compressive strength testing and computed tomography (CT).
References
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