NIH Image to ImageJ: 25 years of image analysis
TLDR
The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.Abstract:
For the past 25 years NIH Image and ImageJ software have been pioneers as open tools for the analysis of scientific images. We discuss the origins, challenges and solutions of these two programs, and how their history can serve to advise and inform other software projects.read more
Citations
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Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center
James Marks,Krishna Kannan,Emily J. Roncase,Dorota Klepacki,Amira Kefi,Cédric Orelle,Nora Vazquez-Laslop,Alexander S. Mankin +7 more
TL;DR: It is shown that the activity of chloramphenicol and linezolid critically depends on the nature of specific amino acids of the nascent chain carried by the ribosome and by the identity of the residue entering the A site, which indicates that the nascent protein modulates the properties of the Ribosomal catalytic center and affects binding of its ligands.
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Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites
Carlo Breda,Korrapati V. Sathyasaikumar,Shama Sograte Idrissi,Francesca M. Notarangelo,Jasper G. Estranero,Gareth G. L. Moore,Edward W. Green,Charalambos P. Kyriacou,Robert Schwarcz,Flaviano Giorgini +9 more
TL;DR: It is found that increased levels of KYNA relative to 3-HK are likely central to the protection conferred by TDO inhibition in a fruit fly model of Huntington’s disease and that TRP treatment strongly reduces neurodegeneration by shifting KP flux toward KYNA synthesis.
Journal ArticleDOI
Sun Navigation Requires Compass Neurons in Drosophila
Ysabel Milton Giraldo,Katherine J. Leitch,Ivo G. Ros,Timothy L. Warren,Timothy L. Warren,Timothy L. Warren,Peter T. Weir,Michael H. Dickinson +7 more
TL;DR: Using a flight simulator, it is found that Drosophila adopt arbitrary headings with respect to a simulated sun, thus performing menotaxis, and individuals remember their heading preference between successive flights-even over several hours.
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Visually induced initiation of Drosophila innate courtship-like following pursuit is mediated by central excitatory state
Soh Kohatsu,Daisuke Yamamoto +1 more
TL;DR: It is reported that moving light spots can induce courtship-like following pursuit in tethered wild-type male flies provided the fly is primed by optogenetic stimulation of specific dsx-expressing neuronal clusters in the lateral protocerebrum (LPR).
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The NAD + -mediated self-inhibition mechanism of pro-neurodegenerative SARM1
TL;DR: The cryo-EM structures of full-length Sarm1 proteins at 2.6- to 3.0-Å resolution have suggested the novel NAD+-mediated self-inhibition of this central pro-neurodegenerative protein.
References
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