NIH Image to ImageJ: 25 years of image analysis
TLDR
The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.Abstract:
For the past 25 years NIH Image and ImageJ software have been pioneers as open tools for the analysis of scientific images. We discuss the origins, challenges and solutions of these two programs, and how their history can serve to advise and inform other software projects.read more
Citations
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Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL.
Maria Giovanna De Leo,Leopoldo Staiano,Mariella Vicinanza,Alessandro Luciani,Annamaria Carissimo,Margherita Mutarelli,Antonella Di Campli,Elena Polishchuk,Giuseppe Di Tullio,Valentina Morra,Elena Levtchenko,Francesca Oltrabella,Tobias Starborg,Michele Santoro,Diego di Bernardo,Olivier Devuyst,Martin Lowe,Diego L. Medina,Andrea Ballabio,Maria Antonietta De Matteis +19 more
TL;DR: A lysosomal response to the arrival of autophagosomal cargo in which OCRL plays a key part is unveiled, and boosting the activity of mucolipin-1 with selective agonists restores the autophagic flux in cells from Lowe syndrome patients.
Journal ArticleDOI
Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation.
Veit Rothhammer,Jessica E. Kenison,Emily C. Tjon,Maisa C. Takenaka,Kalil Alves de Lima,Davis M. Borucki,Chun-Cheih Chao,Annabel Wilz,Manon Blain,Luke M. Healy,Jack P. Antel,Francisco J. Quintana,Francisco J. Quintana +12 more
TL;DR: It is demonstrated that the sphingosine 1-phosphate receptor (S1PR) modulator fingolimod (FTY720) ameliorated chronic progressive experimental autoimmune encephalomyelitis in nonobese diabetic mice, an experimental model that resembles several aspects of SPMS, including neurodegeneration and disease progression driven by the innate immune response in the CNS.
Journal ArticleDOI
Improved drought stress tolerance in Arabidopsis by CRISPR/dCas9 fusion with a Histone AcetylTransferase
Joaquin Felipe Roca Paixão,Joaquin Felipe Roca Paixão,François-Xavier Gillet,Thuanne Pires Ribeiro,Caroline Bournaud,Isabela Tristan Lourenço-Tessutti,Daniel D. Noriega,Bruno Paes de Melo,Janice de Almeida-Engler,Maria Fatima Grossi-de-Sa,Maria Fatima Grossi-de-Sa +10 more
TL;DR: It is reported that CRISPRa dCas9HAT is a valuable biotechnological tool to improve drought stress tolerance through the positive regulation of AREB1.
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Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow
TL;DR: Blood flow and diameter pulsations through a thinned-skull cranial window are determined and microspheres moved preferentially in the paravascular space of arteries rather than in the adjacent subarachnoid space or around veins, suggesting low resistance pathways on the surface of the brain that facilitate cerebrospinal fluid flow.
Journal Article
Quantitative and Qualitative Assessment Methods for Biofilm Growth: A Mini-review.
Christina Wilson,Rachel M Lukowicz,Stefan Merchant,Helena Valquier-Flynn,Jeniffer Caballero,Jasmin Sandoval,Macduff O. Okuom,Christopher J. Huber,Tessa Durham Brooks,Erin Wilson,Barbara Clement,Christopher D Wentworth,Andrea E. Holmes +12 more
TL;DR: This mini-review focuses on enriching interdisciplinary efforts and understanding by overviewing a variety of quantitative and qualitative biofilm characterization methods to assist the novice researcher in assay selection.
References
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