NIH Image to ImageJ: 25 years of image analysis
TLDR
The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.Abstract:
For the past 25 years NIH Image and ImageJ software have been pioneers as open tools for the analysis of scientific images. We discuss the origins, challenges and solutions of these two programs, and how their history can serve to advise and inform other software projects.read more
Citations
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Parathyroid Hormone (PTH)/PTH-related Peptide Type 1 Receptor (PPR) Signaling in Osteocytes Regulates Anabolic and Catabolic Skeletal Responses to PTH
Vaibhav Saini,Dean A. Marengi,Kevin J. Barry,Keertik Fulzele,Erica Heiden,Xiaolong Liu,Christopher Dedic,Akira Maeda,Sutada Lotinun,Roland Baron,Paola Divieti Pajevic +10 more
TL;DR: Data indicate that PPR signaling in osteocytes is required for bone remodeling, and receptor signaling in boneocytes is needed for anabolic and catabolic skeletal responses.
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Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy
Alessandra Moretti,LM Fonteyne,Florian Giesert,Petra Hoppmann,A. B. Meier,Tarik Bozoglu,Andrea Baehr,Christine M. Schneider,Daniel Sinnecker,Katharina Klett,Thomas Fröhlich,F. Abdel Rahman,T. Haufe,Shicheng Sun,Victoria Jurisch,Barbara Kessler,Rabea Hinkel,Ralf J. Dirschinger,Eimo Martens,C. Jilek,Alexander Graf,Stefan Krebs,Gianluca Santamaria,Mayuko Kurome,V. Zakhartchenko,B. Campbell,K. Voelse,Anja Wolf,Tilman Ziegler,S. Reichert,Seungmin Lee,Florian Flenkenthaler,Tatjana Dorn,Irmela Jeremias,Helmut Blum,Andreas Dendorfer,Angelika Schnieke,S Krause,M. C. Walter,Nikolai Klymiuk,Karl-Ludwig Laugwitz,Eckhard Wolf,Wolfgang Wurst,Wolfgang Wurst,Christian Kupatt +44 more
TL;DR: CRISPR–Cas9-mediated gene editing restores dystrophin expression in both pig and human induced pluripotent stem cell models of Duchenne muscular dystrophy, with beneficial effects on skeletal muscle and cardiac function.
Journal ArticleDOI
Effects of graphene oxide aggregates on hydration degree, sorptivity, and tensile splitting strength of cement paste
TL;DR: In this article, the effects of graphene oxide (GO) aggregates on the degree of hydration, sorptivity, and tensile strength of cement paste were investigated, and it has been found the graphene oxide aggregates form in cement paste due to the chemical cross-linking of calcium cations.
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Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver
Michael E. Fusakio,Jeffrey A. Willy,Yongping Wang,Emily T. Mirek,Rana J. T. Al Baghdadi,Christopher M. Adams,Tracy G. Anthony,Ronald C. Wek +7 more
TL;DR: Whole-body and liver-specific ATF4–knockout mice are used to evaluate the role of ATF4 transcription factor in the unfolded protein response (UPR).
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Bufalin is a potent small molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1
Ying Wang,David M. Lonard,Yang Yu,Dar-Chone Chow,Timothy Palzkill,Jin Wang,Ruogu Qi,Alexander J. Matzuk,Xianzhou Song,Franck Madoux,Peter Hodder,Peter Chase,Patrick R. Griffin,Suoling Zhou,Lan Liao,Jianming Xu,Bert W. O'Malley +16 more
TL;DR: Bufalin strongly promoted SRC-3 protein degradation and was able to block cancer cell growth at nanomolar concentrations and is identified as a potentially broad-spectrum small-molecule inhibitor for cancer.
References
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