Targeting neoantigens for cancer immunotherapy.
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This review systematically summarizes recent advances in the identification of both personalized and public neoantigens, neoantigen formulations and neoantsigen-based clinical trials in this review and discusses future techniques and strategies for neoantige-based cancer treatment.Abstract:
Neoantigens, a type of tumor-specific antigens derived from non-synonymous mutations, have recently been characterized as attractive targets for cancer immunotherapy. Owing to the development of next-generation sequencing and utilization of machine-learning algorithms, it has become feasible to computationally predict neoantigens by depicting genetic alterations, aberrant post-transcriptional mRNA processing and abnormal mRNA translation events within tumor tissues. Consequently, neoantigen-based therapies such as cancer vaccines have been widely tested in clinical trials and have demonstrated promising safety and efficacy, opening a new era for cancer immunotherapy. We systematically summarize recent advances in the identification of both personalized and public neoantigens, neoantigen formulations and neoantigen-based clinical trials in this review. Moreover, we discuss future techniques and strategies for neoantigen-based cancer treatment either as a monotherapy or as a combination therapy with radiotherapy, chemotherapy or immune checkpoint inhibitors.read more
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Neoantigens: promising targets for cancer therapy
TL;DR: Neoantigens are newly formed antigens generated by tumor cells as a result of various tumor-specific alterations, such as genomic mutation, dysregulated RNA splicing, disordered post-translational modification, and integrated viral open reading frames as mentioned in this paper .
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Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy
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Identification of Neoantigens in Cancer Cells as Targets for Immunotherapy
TL;DR: Recent progress in the identification of neoantigens is summarized and the issues remaining to be addressed before clinical applications of these new therapeutic strategies can be materialized are discussed.
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Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging
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Magnetic hyperthermia induces effective and genuine immunogenic tumor cell death with respect to exogenous heating.
Bin Yan,Chen Liu,Siyao Wang,Hugang Li,Ju Jiao,Wee Siang Vincent Lee,Song Zhang,Yayi Hou,Yuzhu Hou,Xiaowei Ma,Haiming Fan,Yi Lv,Xiaoli Liu +12 more
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TL;DR: The Global Burden of Disease 2015 Study provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015, finding several countries in sub-Saharan Africa had very large gains in life expectancy, rebounding from an era of exceedingly high loss of life due to HIV/AIDS.
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Lindsey R. Baden,Hana M. El Sahly,Brandon Essink,Karen L. Kotloff,Sharon E. Frey,Rick Novak,David Diemert,Stephen A. Spector,Nadine Rouphael,C. Buddy Creech,John W McGettigan,Shishir Khetan,Nathan Segall,Joel Solis,Adam Brosz,Carlos Fierro,Howard J. Schwartz,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,John R. Mascola,Laura Polakowski,Julie E. Ledgerwood,Barney S. Graham,Hamilton Bennett,Rolando Pajon,Conor Knightly,Brett Leav,Weiping Deng,Honghong Zhou,Shu Liang Han,Melanie Ivarsson,Jacqueline Miller,Tal Z Zaks +36 more
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