Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Mathias Gelderblom,Frank Leypoldt,Karin Steinbach,Doerthe Behrens,Chi-Un Choe,Dominic A. Siler,Thiruma V. Arumugam,Ellen Orthey,Christian Gerloff,Eva Tolosa,Tim Magnus +10 more
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TLDR
The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation.Abstract:
Background and Purpose— Ischemic stroke leads to significant morbidity and mortality in the Western world Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage The understanding of postischemic inflammation is very limited The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia–reperfusion injury model Methods— Transient middle cerebral artery occlusion was induced for 1 hour followed by 12-hour to 7-day reperfusion in C57/BL6 mice Immunohistochemistry and flow cytometry were used to quantify the infiltrating immune cell subsets Results— Accumulation of microglia and infiltration of the ischemic hemisphere by macrophages, lymphocytes, and dendritic cells (DCs) preceded the neutrophilic influx DCs were found to increase 20-fold and constituted a substantial proportion of infiltrating cells DCs exhiread more
Citations
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Book ChapterDOI
Neuroprotection Following Stroke
TL;DR: In this paper , the authors present a review of failed clinical trials for the processes involved in the "ischemic cascade", including excitotoxicity, oxidative stress and inflammation, and assess the benefits of these promising strategies.
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A preclinical randomized multicenter trial of anti-IL-17A treatment for acute ischemic stroke
Mathias Gelderblom,Koch S,Jan-Kolja Strecker,Jørgensen C,Lidia Garcia-Bonilla,Peter Ludewig,Christian Bernreuther,Hans O. Pinnschmidt,Thiruma V. Arumugam,Goetz Thomalla,Cornelius Faber,Jan Sedlacik,Christian Gerloff,Jens Minnerup,Bettina Hjelm Clausen,Josef Anrather,Tim Magnus +16 more
TL;DR: In this article, the authors investigated the efficacy of IL-17A neutralizing antibodies in a multicentric randomized controlled trial (pRCT) using a murine stroke model and found that the neutralization significantly reduced infarct sizes and neutrophil invasion into ischemic cortices.
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Regulation of neuroinflammation, resolution, and neuroprotection by diet and gut microbiota
TL;DR: In this article , long-term consumption of Mediterranean and vegetarian diets does not produce dysbiosis and induce beneficial effects on human health by retarding the induction of oxidative stress and neuroinflammation leading to delaying the inset of type 2 diabetes, heart diseases, and neurological disorders.
Book ChapterDOI
Regulatory T Cells in Ischemic Brain Injury
TL;DR: This chapter provides a comprehensive overview of the current knowledge on Treg cells in experimental and clinical stroke and first Treg-targeted therapeutic strategies have been tested.
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Immunology of Ischemic Stroke: Impact, Mechanisms, and Immunomodulatory Therapies
Jia Jia,Jian Cheng +1 more
TL;DR: The pre-existing immune responses as well as the immune responses evoked by cerebral ischemia play essential roles in shaping stroke outcomes, and the therapies that target theimmune responses, especially the immunomodulatory therapies, are promising treatments for ischemic stroke.
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