Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Mathias Gelderblom,Frank Leypoldt,Karin Steinbach,Doerthe Behrens,Chi-Un Choe,Dominic A. Siler,Thiruma V. Arumugam,Ellen Orthey,Christian Gerloff,Eva Tolosa,Tim Magnus +10 more
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TLDR
The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation.Abstract:
Background and Purpose— Ischemic stroke leads to significant morbidity and mortality in the Western world Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage The understanding of postischemic inflammation is very limited The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia–reperfusion injury model Methods— Transient middle cerebral artery occlusion was induced for 1 hour followed by 12-hour to 7-day reperfusion in C57/BL6 mice Immunohistochemistry and flow cytometry were used to quantify the infiltrating immune cell subsets Results— Accumulation of microglia and infiltration of the ischemic hemisphere by macrophages, lymphocytes, and dendritic cells (DCs) preceded the neutrophilic influx DCs were found to increase 20-fold and constituted a substantial proportion of infiltrating cells DCs exhiread more
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Vγ4 T cell-derived IL-17A is essential for amplification of inflammatory cascades in ischemic brain tissue after stroke.
TL;DR: Zhang et al. as mentioned in this paper analyzed the role of Vγ1 and Vγ4 T cells on ischemic brain tissue damage of stroke in a model of experimental stroke.
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Blood as the carrier of ischemic tolerance in rat brain.
Petra Bonova,Miroslav Gottlieb +1 more
TL;DR: The remote ischemia induced reduction of infarct volume in the preconditioned group as well as in the postconditioned group, and significant diminution was also observed in group XII, indicating a cumulative, stronger tolerance response.
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Correlation of the systemic immune-inflammation index with short- and long-term prognosis after acute ischemic stroke
Nan Wang,Yingying Yang,Baoshan Qiu,Ying Gao,Anxin Wang,Qin Xu,Xia Meng,Yuming Xu,Bo Song,Yongjun Wang,Ying Wang +10 more
TL;DR: The SII was closely related to the short- and long-term prognosis of patients with acute ischemic stroke, and patients with higher SIIs were more likely to have poor outcomes.
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Changes in neocortical and hippocampal microglial cells during hibernation.
Gonzalo León-Espinosa,Mamen Regalado-Reyes,Javier DeFelipe,Javier DeFelipe,Alberto Muñoz,Alberto Muñoz,Alberto Muñoz +6 more
TL;DR: It is discussed the possibility that microglia morphological changes that occur in the neocortex and hippocampus of the Syrian hamster during hibernation may contribute to neuronal damage prevention During hibernation.
BookDOI
Translational Research in Stroke
Paul A. Lapchak,Guo-Yuan. Yang +1 more
TL;DR: The benefit of testing novel neuroprotective and cytoprotective therapies as an adjuvant in the patient population defined above will take advantage of both largepenumbra and reperfusion of the penumbra, and the recommendation is for translational research to be conducted in standardized and validated embolic stroke models.
References
More filters
Journal ArticleDOI
Pathobiology of ischaemic stroke: an integrated view
TL;DR: This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain.
Journal ArticleDOI
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
TL;DR: This review focuses on several key observations that illustrate the multi-faceted activities of microglia in the normal and pathologic brain.
Journal ArticleDOI
Taking dendritic cells into medicine
TL;DR: Some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy are presented.
Journal ArticleDOI
The inflammatory response in stroke.
TL;DR: The role of specific cell types including leukocytes, endothelium, glia, microglia, the extracellular matrix and neurons, and mediators produced by inflammatory cells such as cytokines, chemokines, reactive oxygen species and arachidonic acid metabolites are reviewed.
Journal ArticleDOI
A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells.
TL;DR: A synthetic glycolipid ligand for CD1d-restricted natural killer T (NKT) cells expressing the semi-invariant T-cell receptor (Vα14+) is preventive against EAE and targeting NKT cells with this ligand may be an attractive means for intervening in human autoimmune diseases such as multiple sclerosis.