Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Mathias Gelderblom,Frank Leypoldt,Karin Steinbach,Doerthe Behrens,Chi-Un Choe,Dominic A. Siler,Thiruma V. Arumugam,Ellen Orthey,Christian Gerloff,Eva Tolosa,Tim Magnus +10 more
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TLDR
The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation.Abstract:
Background and Purpose— Ischemic stroke leads to significant morbidity and mortality in the Western world Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage The understanding of postischemic inflammation is very limited The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia–reperfusion injury model Methods— Transient middle cerebral artery occlusion was induced for 1 hour followed by 12-hour to 7-day reperfusion in C57/BL6 mice Immunohistochemistry and flow cytometry were used to quantify the infiltrating immune cell subsets Results— Accumulation of microglia and infiltration of the ischemic hemisphere by macrophages, lymphocytes, and dendritic cells (DCs) preceded the neutrophilic influx DCs were found to increase 20-fold and constituted a substantial proportion of infiltrating cells DCs exhiread more
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Integrating metabolomics and network pharmacology to explore the protective effect of gross saponins of Tribulus terrestris L. fruit against ischemic stroke in rat.
Wenjun Guo,Yang Wang,Yang Wang,Meiling Fan,Shengxu Xie,Hongyu Zhao,Jifeng Wang,Yue Liu,Dong-Ming Xu,Yajuan Xu +9 more
TL;DR: The present study combines metabolomics and network pharmacology analysis to investigate the mechanism of MCAO-induced isChemic stroke and reveal the efficiency and possible mechanisms of GSTTF for ischemic stroke.
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T Cell Response in Ischemic Stroke: From Mechanisms to Translational Insights.
TL;DR: In this article, a review summarizes the mediators of T cell recruitment, as well as the temporal course of its infiltration through the blood-brain-barrier, choroid plexus, and meningeal pathways.
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Is Immunomodulation a Principal Mechanism Underlying How Cell-Based Therapies Enhance Stroke Recovery?
Nikunj Satani,Sean I Savitz +1 more
TL;DR: Different types of cellular therapies are explored and how they modulate central and peripheral inflammatory processes after stroke are discussed, including paracrine and immunomodulatory mechanisms of cell therapy.
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The Roles of Monocyte and Monocyte-Derived Macrophages in Common Brain Disorders.
TL;DR: The current knowledge about the role of monocytes and monocyte-derived macrophages during several common brain disorders, which include ischemic stroke, Alzheimer's disease, multiple sclerosis, intracerebral hemorrhage, and insomnia are summarized.
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Dietary salt promotes ischemic brain injury and is associated with parenchymal migrasome formation.
Antje Schmidt-Pogoda,Jan-Kolja Strecker,Marie Liebmann,Christina Massoth,Carolin Beuker,Uwe Hansen,Simone König,Sarah Albrecht,Stefanie Bock,Johanna Breuer,Clemens Sommer,Nicholas Schwab,Heinz Wiendl,Luisa Klotz,Jens Minnerup +14 more
TL;DR: It is demonstrated that high-salt diet aggravates stroke outcomes, and the migrasome is characterized as a novel mechanism in acute stroke pathophysiology.
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