Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Mathias Gelderblom,Frank Leypoldt,Karin Steinbach,Doerthe Behrens,Chi-Un Choe,Dominic A. Siler,Thiruma V. Arumugam,Ellen Orthey,Christian Gerloff,Eva Tolosa,Tim Magnus +10 more
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TLDR
The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation.Abstract:
Background and Purpose— Ischemic stroke leads to significant morbidity and mortality in the Western world Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage The understanding of postischemic inflammation is very limited The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia–reperfusion injury model Methods— Transient middle cerebral artery occlusion was induced for 1 hour followed by 12-hour to 7-day reperfusion in C57/BL6 mice Immunohistochemistry and flow cytometry were used to quantify the infiltrating immune cell subsets Results— Accumulation of microglia and infiltration of the ischemic hemisphere by macrophages, lymphocytes, and dendritic cells (DCs) preceded the neutrophilic influx DCs were found to increase 20-fold and constituted a substantial proportion of infiltrating cells DCs exhiread more
Citations
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Friend or foe? – B cells in stroke
TL;DR: This review will focus on the role of B cells in the ischemic brain and describe possible antibody-dependent and antibody-independent mechanisms in the development of post-stroke cognitive deficits.
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Depletion of iNOS-positive inflammatory cells decelerates neuronal degeneration and alleviates cerebral ischemic damage by suppressing the inflammatory response.
TL;DR: In this paper , the role of inflammatory cells in ischemic stroke has not been fully elucidated, but it is shown that depletion of iNOS+ inflammatory cells significantly restrained the production of pro-inflammatory cytokines, which moderated the immune microenvironment at lesion site.
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Correction to: Neuroimmune Response in Ischemic Preconditioning
TL;DR: A mechanistic understanding of cellular, molecular, and systemic elements of the immune response in IPC may not only facilitate more effective direct application of IPC to specific clinical scenarios, but also reveal novel targets for therapeutic intervention in stroke.
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Platelets, Thromboinflammation and Neurovascular Disease
Ying Sun,Harald F. Langer +1 more
TL;DR: In this paper , the activation and response mechanisms of innate and adaptive immune processes in response to neuroinflammation are discussed, and the clinical importance of neuroinflammatory mediators and a potential translational relevance of involved mechanisms are addressed also with focus on non-classical immune cells including microglia cells or platelets.
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Perioperative Factors Associated With Chronic Central Pain After the Resection of Intramedullary Spinal Cord Tumor.
Yuki Onishi-Kato,Masaya Nakamura,Akio Iwanami,Masayoshi Kato,Takeshi Suzuki,Shizuko Kosugi,Nobuyuki Katori,Saori Hashiguchi,Koichi Tsuzaki,Junzo Takeda,Hiroshi Morisaki +10 more
TL;DR: Investigation of perioperative factors associated with chronic pain after IMSCT resection found decline in JOA score, intraoperative hypotension, and postoperative corticosteroids are independently associated with postsurgical chronic central pain.
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