Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Mathias Gelderblom,Frank Leypoldt,Karin Steinbach,Doerthe Behrens,Chi-Un Choe,Dominic A. Siler,Thiruma V. Arumugam,Ellen Orthey,Christian Gerloff,Eva Tolosa,Tim Magnus +10 more
Reads0
Chats0
TLDR
The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation.Abstract:
Background and Purpose— Ischemic stroke leads to significant morbidity and mortality in the Western world Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage The understanding of postischemic inflammation is very limited The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia–reperfusion injury model Methods— Transient middle cerebral artery occlusion was induced for 1 hour followed by 12-hour to 7-day reperfusion in C57/BL6 mice Immunohistochemistry and flow cytometry were used to quantify the infiltrating immune cell subsets Results— Accumulation of microglia and infiltration of the ischemic hemisphere by macrophages, lymphocytes, and dendritic cells (DCs) preceded the neutrophilic influx DCs were found to increase 20-fold and constituted a substantial proportion of infiltrating cells DCs exhiread more
Citations
More filters
Journal ArticleDOI
Intracerebroventricular Delivery of Recombinant NAMPT Deters Inflammation and Protects Against Cerebral Ischemia
Fenghua Chen,Fenghua Chen,Zhongfang Weng,Zhongfang Weng,Qinghai Xia,Catherine Cao,Rehana K. Leak,Lihong Han,Jian Xiao,Steven H. Graham,Steven H. Graham,Guodong Cao,Guodong Cao +12 more
TL;DR: Results indicate that NAMPT may protect against ischemic brain injury partly through a novel anti-inflammatory mechanism, which in turn maintains BBB integrity and reduces the infiltration of peripheral inflammatory cells.
Journal ArticleDOI
Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats.
Shufeng Yu,Shufeng Yu,Desislava Doycheva,Marcin Gamdzyk,Yijun Yang,Cameron Lenahan,Cameron Lenahan,Gaigai Li,Gaigai Li,Dujuan Li,Lifei Lian,Lifei Lian,Jiping Tang,Jun Lu,John H. Zhang +14 more
TL;DR: In this paper, the role of melanocortin-1 receptor activation on neuroinflammation and the potential underlying mechanisms after neonatal hypoxic-ischemic brain injury in rats were explored.
Journal ArticleDOI
Mechanisms Underlying the Protective Effect of the Peroxiredoxin-6 Are Mediated via the Protection of Astrocytes during Ischemia/Reoxygenation.
TL;DR: In this article, the effect of peroxiredoxin-6 (Prx-6) on hippocampal cells during oxygen-glucose deprivation/reoxygenation (OGD/R) was investigated.
Journal ArticleDOI
Combined Treatment With Dichloroacetic Acid and Pyruvate Reduces Hippocampal Neuronal Death After Transient Cerebral Ischemia.
Dae Ki Hong,A Ra Kho,Bo Young Choi,Song Hee Lee,Jeong Hyun Jeong,Sang Hwon Lee,Kyoung-Ha Park,Jae-Bong Park,Sang Won Suh +8 more
TL;DR: It is demonstrated that the combined administration of DCA with pyruvate significantly decreased neuronal death, oxidative stress, microglia activation when compared with DCA, or pyruVate injection alone, and suggest that the administration of Dichloroacetic acid with pyrivate may enhance essential metabolic processes, which in turn promotes the regenerative capacity of the post-ischemic brain.
Journal ArticleDOI
Neutrophil Extracellular Traps in Coronavirus Disease-19-Associated Ischemic Stroke: A Novel Avenue in Neuroscience
Tjokorda Istri Pramitasuri,Anak Agung Ayu Putri Laksmidewi,Ida Bagus Kusuma Putra,Felix Adrian Dalimartha +3 more
TL;DR: In this paper, the authors established an overview of coronaviruses and NETs, NETs in pathogenesis of COVID-19 induced-ischemic stroke, and future directions using related recent literatures.
References
More filters
Journal ArticleDOI
Pathobiology of ischaemic stroke: an integrated view
TL;DR: This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain.
Journal ArticleDOI
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
TL;DR: This review focuses on several key observations that illustrate the multi-faceted activities of microglia in the normal and pathologic brain.
Journal ArticleDOI
Taking dendritic cells into medicine
TL;DR: Some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy are presented.
Journal ArticleDOI
The inflammatory response in stroke.
TL;DR: The role of specific cell types including leukocytes, endothelium, glia, microglia, the extracellular matrix and neurons, and mediators produced by inflammatory cells such as cytokines, chemokines, reactive oxygen species and arachidonic acid metabolites are reviewed.
Journal ArticleDOI
A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells.
TL;DR: A synthetic glycolipid ligand for CD1d-restricted natural killer T (NKT) cells expressing the semi-invariant T-cell receptor (Vα14+) is preventive against EAE and targeting NKT cells with this ligand may be an attractive means for intervening in human autoimmune diseases such as multiple sclerosis.