Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Mathias Gelderblom,Frank Leypoldt,Karin Steinbach,Doerthe Behrens,Chi-Un Choe,Dominic A. Siler,Thiruma V. Arumugam,Ellen Orthey,Christian Gerloff,Eva Tolosa,Tim Magnus +10 more
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TLDR
The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation.Abstract:
Background and Purpose— Ischemic stroke leads to significant morbidity and mortality in the Western world Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage The understanding of postischemic inflammation is very limited The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia–reperfusion injury model Methods— Transient middle cerebral artery occlusion was induced for 1 hour followed by 12-hour to 7-day reperfusion in C57/BL6 mice Immunohistochemistry and flow cytometry were used to quantify the infiltrating immune cell subsets Results— Accumulation of microglia and infiltration of the ischemic hemisphere by macrophages, lymphocytes, and dendritic cells (DCs) preceded the neutrophilic influx DCs were found to increase 20-fold and constituted a substantial proportion of infiltrating cells DCs exhiread more
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Dynamic Status of SII and SIRI Alters the Risk of Cardiovascular Diseases: Evidence from Kailuan Cohort Study
Jun Li,Di He,Jiazhou Yu,Shuohua Chen,Qiong Wu,Zongxue Cheng,Qiaohui Wei,Yuying Xu,Yimin Zhu,Shou Ling Wu +9 more
TL;DR: Dynamic status of SII and SIRI was significantly associated with risk of CVD, which highlighted that the next study should focus on the dynamic change of S II and S IRI.
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Dynamic Status of SII and SIRI Alters the Risk of Cardiovascular Diseases: Evidence from Kailuan Cohort Study
TL;DR: In this paper , the authors examined the association between the dynamic status of SII and SIRI and risk of cardiovascular diseases (CVD) and found that SII is prone to change over time and is associated with increased risk of CVD.
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Neutrophil affinity for PGP and HAIYPRH (T7) peptide dual-ligand functionalized nanoformulation enhances the brain delivery of tanshinone IIA and exerts neuroprotective effects against ischemic stroke by inhibiting proinflammatory signaling pathways
Yutao Li,Chiying An,Danan Han,Yanxin Dang,Xin Liu,Xin Liu,Feng-Ming Zhang,Yuan Xu,Haijing Zhong,Xiao-Jun Sun +9 more
TL;DR: A novel ischemic inflammatory site-recognizing and BBB-penetrating dual-targeting nano-drug system that has been proved to be a high-loading formulation for the neuroprotective compound, tanshinone IIA, and significantly improved its brain accumulation and therapeutic efficacy in a rodent model of isChemic stroke.
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Histone Methyltransferase Dot1L Contributes to RIPK1 Kinase-Dependent Apoptosis in Cerebral Ischemia/Reperfusion.
TL;DR: In this article, the role and mechanism of Dot1L on cerebral ischemia is investigated, and it is shown that blocking or inhibition of DotL in vivo attenuates apoptosis in middle cerebral artery occlusion mice and reduces the extent of brain injury.
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Adenosine and Stroke
TL;DR: Information suggests that A2A receptors are a potentially attractive therapeutic target in ischemia, and it can be speculated that A3 receptor selective ligands may be useful in the treatment of ischemic conditions involving inflammation.
References
More filters
Journal ArticleDOI
Pathobiology of ischaemic stroke: an integrated view
TL;DR: This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain.
Journal ArticleDOI
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
TL;DR: This review focuses on several key observations that illustrate the multi-faceted activities of microglia in the normal and pathologic brain.
Journal ArticleDOI
Taking dendritic cells into medicine
TL;DR: Some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy are presented.
Journal ArticleDOI
The inflammatory response in stroke.
TL;DR: The role of specific cell types including leukocytes, endothelium, glia, microglia, the extracellular matrix and neurons, and mediators produced by inflammatory cells such as cytokines, chemokines, reactive oxygen species and arachidonic acid metabolites are reviewed.
Journal ArticleDOI
A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells.
TL;DR: A synthetic glycolipid ligand for CD1d-restricted natural killer T (NKT) cells expressing the semi-invariant T-cell receptor (Vα14+) is preventive against EAE and targeting NKT cells with this ligand may be an attractive means for intervening in human autoimmune diseases such as multiple sclerosis.