Journal ArticleDOI
Why is depression more common among women than among men
TLDR
Evidence regarding the epidemiology on gender differences in prevalence, incidence, and course of depression, and factors possibly explaining the gender gap are summarized.About:
This article is published in The Lancet Psychiatry.The article was published on 2017-02-01. It has received 754 citations till now.read more
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Journal ArticleDOI
Trends in depression prevalence in the USA from 2005 to 2015: widening disparities in vulnerable groups
Andrea H. Weinberger,Misato Gbedemah,Antigona Martinez,Denis Nash,Sandro Galea,Renee D. Goodwin +5 more
TL;DR: The prevalence of depression increased significantly in the USA from 2005 to 2015 and the rate of increase in depression among youth was significantly more rapid relative to older groups.
Journal ArticleDOI
Association of loneliness with all-cause mortality: A meta-analysis.
Laura Alejandra Rico-Uribe,Francisco Félix Caballero,Francisco Félix Caballero,Natalia Martín-María,Natalia Martín-María,Maria Cabello,Maria Cabello,José Luis Ayuso-Mateos,José Luis Ayuso-Mateos,Marta Miret,Marta Miret +10 more
TL;DR: Loneliness shows a harmful effect for all-cause mortality and this effect is slightly stronger in men than in women, which was independent from the quality evaluation of each article and the effect of depression.
Journal ArticleDOI
Animal models of major depression: drawbacks and challenges.
TL;DR: The validity of animal models of major depression, putative models of treatment-resistant depression, major depression subtypes and recurrent depression are discussed, and future challenges regarding new paradigms such as those proposing dimensional rather than categorical approaches to depression are identified.
Journal ArticleDOI
Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions
TL;DR: It is concluded that deficits in cortical inhibitory neurotransmission and interneuron function resulting from chronic stress exposure can compromise the integrity of neurocircuits and result in the development of MDD and other stress-related disorders.
References
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Journal ArticleDOI
The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Doreen S. Koretz,Kathleen R. Merikangas,A. John Rush,Ellen E. Walters,Philip S. Wang +8 more
TL;DR: Notably, major depressive disorder is a common disorder, widely distributed in the population, and usually associated with substantial symptom severity and role impairment, and while the recent increase in treatment is encouraging, inadequate treatment is a serious concern.
Journal ArticleDOI
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
Journal ArticleDOI
The size and burden of mental disorders and other disorders of the brain in Europe 2010
Hans-Ulrich Wittchen,Frank Jacobi,Jürgen Rehm,Jürgen Rehm,Anders Gustavsson,Mikael Svensson,Bengt Jönsson,Jes Olesen,Christer Allgulander,Jordi Alonso,Carlo Faravelli,Laura Fratiglioni,Poul Jennum,Roselind Lieb,Andreas Maercker,J. van Os,Martin Preisig,Luis Salvador-Carulla,Roland Simon,Hans-Christoph Steinhausen,Hans-Christoph Steinhausen,Hans-Christoph Steinhausen +21 more
TL;DR: The true size and burden of disorders of the brain in the EU was significantly underestimated in the past, and Concerted priority action is needed at all levels, including substantially increased funding for basic, clinical and public health research and policy decisions.
Journal ArticleDOI
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
TL;DR: A meta-analysis of relevant data from primary studies of the genetic epidemiology of major depression suggested that familial aggregation was due to additive genetic effects, with a minimal contribution of environmental effects common to siblings and substantial individual-specific environmental effects/measurement error.
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