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Kai How Farh

Researcher at Harvard University

Publications -  5
Citations -  7679

Kai How Farh is an academic researcher from Harvard University. The author has contributed to research in topics: Copy-number variation & Genome-wide association study. The author has an hindex of 5, co-authored 5 publications receiving 6167 citations. Previous affiliations of Kai How Farh include Broad Institute & University of Southern California.

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Journal ArticleDOI

Integrative analysis of 111 reference human epigenomes

Anshul Kundaje, +123 more
- 19 Feb 2015 - 
TL;DR: It is shown that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease.
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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Bjarni J. Vilhjálmsson, +394 more
- 01 Oct 2015 - 
TL;DR: LDpred is introduced, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel, and outperforms the approach of pruning followed by thresholding, particularly at large sample sizes.
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Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Christian R. Marshall, +329 more
- 01 Jan 2017 - 
TL;DR: In this article, a centralized analysis pipeline was applied to a SCZ cohort of 21,094 cases and 20,227 controls, and a global enrichment of copy number variants (CNVs) was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10-15), which persisted after excluding loci implicated in previous studies.
Posted ContentDOI

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

Christian R. Marshall, +255 more
- 23 Feb 2016 - 
TL;DR: A collaborative effort in which a centralized analysis pipeline is applied to a SCZ cohort, finding support at a suggestive level for nine additional candidate susceptibility and protective loci, which consist predominantly of CNVs mediated by non-allelic homologous recombination (NAHR).
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Age at first birth in women is genetically associated with increased risk of schizophrenia

Guiyan Ni, +365 more
- 05 Jul 2018 - 
TL;DR: The results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample, contributing new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.