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Leonora Balaj

Researcher at Harvard University

Publications -  80
Citations -  16354

Leonora Balaj is an academic researcher from Harvard University. The author has contributed to research in topics: Microvesicles & Liquid biopsy. The author has an hindex of 36, co-authored 71 publications receiving 10867 citations. Previous affiliations of Leonora Balaj include VU University Medical Center & Poznan University of Medical Sciences.

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Théry, +417 more
TL;DR: The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.
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Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

TL;DR: Tumour microvesicles contain a repertoire of genetic information available for horizontal gene transfer and potential use as blood biomarkers for cancer, including elevated levels of specific coding and non-coding RNA and DNA, mutated and amplified oncogene sequences and transposable elements.
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Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

TL;DR: This article will focus on EV composition, mechanisms of uptake, and their biological effects on recipient cells, and established and recently developed methods used to study EVs, including isolation, quantification, labeling and imaging protocols, as well as RNA analysis.
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Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

TL;DR: It is shown that circulating GBM microvesicles can be used to analyze primary tumor mutations and as a predictive metric of treatment-induced changes and could provide both an early indicator of drug efficacy and a potential molecular stratifier for human clinical trials.
Journal Article

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

TL;DR: In this article, a highly sensitive and rapid analytical technique for profiling circulating microvesicles directly from blood samples of patients with glioblastoma multiforme (GBM) was described.