Ohio State University

About: Ohio State University is a education organization based out in Columbus, Ohio, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 102421 authors who have published 222715 publications receiving 8373403 citations. The organization is also known as: Ohio State & The Ohio State University.

MicroRNA-Cancer Connection: The Beginning of a New Tale

Abstract: Cancer initiation and progression can involve microRNAs (miRNA), which are small noncoding RNAs that can regulate gene expression. Their expression profiles can be used for the classification, diagnosis, and prognosis of human malignancies. Loss or amplification of miRNA genes has been reported in a variety of cancers, and altered patterns of miRNA expression may affect cell cycle and survival programs. Germ-line and somatic mutations in miRNAs or polymorphisms in the mRNAs targeted by miRNAs may also contribute to cancer predisposition and progression. We propose that alterations in miRNA genes play a critical role in the pathophysiology of many, perhaps all, human cancers.

The Fuzzball proposal for black holes: An Elementary review

Abstract: We give an elementary review of black holes in string theory. We discuss BPS holes, the microscopic computation of entropy and the `fuzzball' picture of the black hole interior suggested by microstates of the 2-charge system.

Teachers’ Professional Community in Restructuring Schools

Abstract: Professional community among teachers, the subject of a number of recent major studies, is regarded as an ingredient that may contribute to the improvement of schools. The research reported in this article is grounded in the assumption that how teachers interact with each other outside of their classrooms may be critical to the effects of restructuring on students. The analysis focuses on the type of professional community that occurs within a school and investigates both the organizational factors that facilitate its development and its consequences for teachers’ sense of responsibility for student learning. The findings suggest that wide variation in professional community exists between schools, much of which is attributable to both structural features and human resources characteristics, as well as school level. Implications for current school reform efforts are discussed.

The Proton's Absolute Aqueous Enthalpy and Gibbs Free Energy of Solvation from Cluster-Ion Solvation Data

Abstract: A method is presented to determine the absolute hydration enthalpy of the proton, ΔHaq°[H+], from a set of cluster-ion solvation data without the use of extra thermodynamic assumptions. The absolute proton hydration enthalpy has been found to be ∼50 kJ/mol different than traditional values and has been more precisely determined (by about an order of magnitude). Conventional ion solvation properties, based on the standard heat of formation of H+(aq) set to zero, have been devised that may be confusing to the uninitiated but are useful in thermochemical evaluations because they avoid the unnecessary introduction of the larger uncertainties in our knowledge of absolute values. In a similar strategy, we have motivated the need for a reassessment of ΔHaq°[H+] by the trends with increased clustering in conventional cluster-ion solvation enthalpy differences for pairs of oppositely charged cluster ions. The consequences of particular preferred values for ΔHaq°[H+] may be evaluated with regard to cluster-ion prop...

The Information paradox: A Pedagogical introduction

Abstract: The black hole information paradox is a very poorly understood problem. It is often believed that Hawking's argument is not precisely formulated, and a more careful accounting of naturally occurring quantum corrections will allow the radiation process to become unitary. We show that such is not the case, by proving that small corrections to the leading order Hawking computation cannot remove the entanglement between the radiation and the hole. We formulate Hawking's argument as a 'theorem': assuming 'traditional' physics at the horizon and usual assumptions of locality we will be forced into mixed states or remnants. We also argue that one cannot explain away the problem by invoking AdS/CFT duality. We conclude with recent results on the quantum physics of black holes which show that the interior of black holes have a 'fuzzball' structure. This nontrivial structure of microstates resolves the information paradox and gives a qualitative picture of how classical intuition can break down in black hole physics.