Ohio State University

About: Ohio State University is a education organization based out in Columbus, Ohio, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 102421 authors who have published 222715 publications receiving 8373403 citations. The organization is also known as: Ohio State & The Ohio State University.

The Structure of a Social Science Collaboration Network: Disciplinary Cohesion from 1963 to 1999

Abstract: Has sociology become more socially integrated over the last 30 years? Recent work in the sociology of knowledge demonstrates a direct linkage between social interaction patterns and the structure of ideas, suggesting that scientific collaboration networks affect scientific practice. I test three competing models for sociological collaboration networks and find that a structurally cohesive core that has been growing steadily since the early 1960s characterizes the discipline's coauthorship network. The results show that participation in the sociology collaboration network depends on research specialty and that quantitative work is more likely to be coauthored than non-quantitative work. However, structural embeddedness within the network core given collaboration is largely unrelated to specialty area. This pattern is consistent with a loosely overlapping specialty structure that has potentially integrative implications for theoretical development in sociology.

Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations.

Abstract: ContextGermline mutations of the genes encoding succinate dehydrogenase subunits B (SDHB) and D (SDHD) predispose to paraganglioma syndromes type 4 (PGL-4) and type 1 (PGL-1), respectively. In both syndromes, pheochromocytomas as well as head and neck paragangliomas occur; however, details for individual risks and other clinical characteristics are unknown.ObjectiveTo determine the differences in clinical features in carriers of SDHB mutations and SDHD mutations.Design, Setting, and PatientsPopulation-based genetic screening for SDHB and SDHD germline mutations in 417 unrelated patients with adrenal or extra-adrenal abdominal or thoracic pheochromocytomas (n = 334) or head and neck paragangliomas (n = 83), but without syndromic features, from 2 registries based in Germany and central Poland, conducted from April 1, 2000, until May 15, 2004.Main Outcome MeasuresDemographic and clinical findings with respect to gene mutation in SDHB vs SDHD compared with nonmutation carriers.ResultsA total of 49 (12%) of 417 registrants carried SDHB or SDHD mutations. In addition, 28 SDHB and 23 SDHD mutation carriers were newly detected among relatives of these carriers. Comparison of 53 SDHB and 47 SDHD total mutation carriers showed similar ages at diagnosis but differences in penetrance and of tumor manifestations. Head and neck paragangliomas (10/32 vs 27/34, respectively, P<.001) and multifocal (9/32 vs 25/34, respectively, P<.001) tumors were more frequent in carriers of SDHD mutations. In contrast, SDHB mutation carriers have an increased frequency of malignant disease (11/32 vs 0/34, P<.001). Renal cell cancer was observed in 2 SDHB mutation carriers and papillary thyroid cancer in 1 SDHB mutation carrier and 1 SDHD mutation carrier.ConclusionsIn contrast with SDHD mutation carriers (PGL-1) who have more frequent multifocal paragangliomas, SDHB mutation carriers (PGL-4) are more likely to develop malignant disease and possibly extraparaganglial neoplasias, including renal cell and thyroid carcinomas. Appropriate and timely clinical screening is recommended in all patients with PGL-1 and PGL-4.

Cats and dogs, hair and a hero: A quintet of new milky way companions

Abstract: We present five new satellites of the Milky Way discovered in Sloan Digital Sky Survey (SDSS) imaging data, four of which were followed-up with either the Subaru or the Isaac Newton Telescopes. They include four probable new dwarf galaxies--one each in the constellations of Coma Berenices, Canes Venatici, Leo and Hercules--together with one unusually extended globular cluster, Segue 1. We provide distances, absolute magnitudes, half-light radii and color-magnitude diagrams for all five satellites. The morphological features of the color-magnitude diagrams are generally well described by the ridge line of the old, metal-poor globular cluster M92. In the last two years, a total of ten new Milky Way satellites with effective surface brightness {mu}{sub v} {approx}> 28 mag arcsec{sup -2} have been discovered in SDSS data. They are less luminous, more irregular and appear to be more metal-poor than the previously-known nine Milky Way dwarf spheroidals. The relationship between these objects and other populations is discussed. We note that there is a paucity of objects with half-light radii between {approx} 40 pc and {approx} 100 pc. We conjecture that this may represent the division between star clusters and dwarf galaxies.

An Introduction to Active Galactic Nuclei

Abstract: How can we test if a supermassive black hole lies at the heart of every active galactic nucleus? What are LINERS, BL Lacs, N galaxies, broad-line radio galaxies and radio-quiet quasars and how do they compare? This timely textbook answers these questions in a clear, comprehensive and self-contained introduction to active galactic nuclei - for graduate students in astronomy and physics. The study of AGN is one of the most dynamic areas of contemporary astronomy, involving one fifth of all research astronomers. This textbook provides a systematic review of the observed properties of AGN across the entire electromagnetic spectrum, examines the underlying physics, and shows how the brightest AGN, quasars, can be used to probe the farthest reaches of the Universe. This book serves as both an entry point to the research literature and as a valuable reference for researchers in the field.