Ohio State University

About: Ohio State University is a education organization based out in Columbus, Ohio, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 102421 authors who have published 222715 publications receiving 8373403 citations. The organization is also known as: Ohio State & The Ohio State University.

Functional impact of global rare copy number variation in autism spectrum disorders

Abstract: The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in reciprocal social interaction and communication, and the presence of restricted and repetitive behaviours. Individuals with an ASD vary greatly in cognitive development, which can range from above average to intellectual disability. Although ASDs are known to be highly heritable ( approximately 90%), the underlying genetic determinants are still largely unknown. Here we analysed the genome-wide characteristics of rare (<1% frequency) copy number variation in ASD using dense genotyping arrays. When comparing 996 ASD individuals of European ancestry to 1,287 matched controls, cases were found to carry a higher global burden of rare, genic copy number variants (CNVs) (1.19 fold, P = 0.012), especially so for loci previously implicated in either ASD and/or intellectual disability (1.69 fold, P = 3.4 x 10(-4)). Among the CNVs there were numerous de novo and inherited events, sometimes in combination in a given family, implicating many novel ASD genes such as SHANK2, SYNGAP1, DLGAP2 and the X-linked DDX53-PTCHD1 locus. We also discovered an enrichment of CNVs disrupting functional gene sets involved in cellular proliferation, projection and motility, and GTPase/Ras signalling. Our results reveal many new genetic and functional targets in ASD that may lead to final connected pathways.

Expanding the utilization of sustainable plant products in aquafeeds: a review

Abstract: Continued growth and intensi¢cation of aquaculture production depends upon the development of sustainable protein sources to replace ¢sh meal in aquafeeds. This document reviews various plant feedstuis, which currently are or potentially may be incorporated into aquafeeds to support the sustainable production of various ¢sh species in aquaculture. The plant feedstuis considered include oilseeds, legumes and cereal grains, which traditionally have been used as protein or energy concentrates as well as novel products developed through various processing technologies. The nutritional composition of these various feedstuis are considered along with the presence of any bioactive compounds that may positively or negatively aiect the target organism. Lipid composition of these feedstuis is not speci¢cally considered although it is recognized that incorporating lipid supplements in aquafeeds to achieve proper fatty acid pro¢les to meet the metabolic requirements of ¢sh and maximize human health bene¢ts are important aspects. Speci¢c strategies and techniques to optimize the nutritional composition of plant feedstuis and limit potentially adverse eiects of bioactive compounds are also described. Such information will provide a foundation for developing strategic research plans for increasing the use of plant feedstuis in aquaculture to reduce dependence of animal feedstuis and thereby enhance the sustainability of aquaculture.

On the Normalization of the Cosmic Star Formation History

Abstract: Strong constraints on the cosmic star formation history (SFH) have recently been established using ultraviolet and far-infrared measurements, refining the results of numerous measurements over the past decade. The data show a compellingly consistent picture of the SFH out to redshift z ≈ 6, with especially tight constraints for z 1. We fit these data with simple analytical forms and derive conservative uncertainties. Since the z 1 SFH data are quite precise, we investigate the sequence of assumptions and corrections that together affect the SFH normalization to test their accuracy, both in this redshift range and beyond. As lower limits on this normalization, we consider the evolution in stellar and metal mass densities, and supernova rate density, finding it unlikely that the SFH normalization is much lower than indicated by our direct fit. As a corresponding upper limit on the SFH normalization, we consider the Super-Kamiokande limit on the electron antineutrino (e) flux from past core-collapse supernovae, which applies primarily to z 1. We find consistency with the SFH only if the neutrino temperatures from supernova events are relatively modest. Constraints on the assumed initial mass function (IMF) also become apparent. The traditional Salpeter IMF, assumed for convenience by many authors, is known to be a poor representation at low stellar masses (1 M☉), and we show that recently favored IMFs are also constrained. In particular, somewhat shallow, or top-heavy, IMFs may be preferred, although they cannot be too top-heavy. To resolve the outstanding issues, improved data are called for on the supernova rate density evolution, the ranges of stellar masses leading to core-collapse and type Ia supernovae, and the antineutrino and neutrino backgrounds from core-collapse supernovae.

MicroRNAs in cancer.

Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation, apoptosis, and migration. Thus, miRNAs have been implicated in the regulation of virtually all signaling circuits within a cell, and their dysregulation has been shown to play an essential role in the development and progression of cancer. Here, after a brief description of miRNA genomics, biogenesis, and function, we discuss the effects of miRNA dysregulation in the cellular pathways that lead to the progressive conversion of normal cells into cancer cells and the potential to develop new molecular miRNA-targeted therapies.