Tohoku University

About: Tohoku University is a education organization based out in Sendai, Japan. It is known for research contribution in the topics: Magnetization & Alloy. The organization has 72116 authors who have published 170791 publications receiving 3941714 citations. The organization is also known as: Tōhoku daigaku.

Optimization of Dosing for EGFR-Mutant Non–Small Cell Lung Cancer with Evolutionary Cancer Modeling

Abstract: Non–small cell lung cancers (NSCLCs) that harbor mutations within the epidermal growth factor receptor (EGFR) gene are sensitive to the tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib. Unfortunately, all patients treated with these drugs will acquire resistance, most commonly as a result of a secondary mutation within EGFR (T790M). Because both drugs were developed to target wild-type EGFR, we hypothesized that current dosing schedules were not optimized for mutant EGFR or to prevent resistance. To investigate this further, we developed isogenic TKI-sensitive and TKI-resistant pairs of cell lines that mimic the behavior of human tumors. We determined that the drug-sensitive and drug-resistant EGFR-mutant cells exhibited differential growth kinetics, with the drug-resistant cells showing slower growth. We incorporated these data into evolutionary mathematical cancer models with constraints derived from clinical data sets. This modeling predicted alternative therapeutic strategies that could prolong the clinical benefit of TKIs against EGFR-mutant NSCLCs by delaying the development of resistance.

Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion

Abstract: Definitive diagnosis of prion disease currently requires postmortem brain tissue. Now, Ryuichiro Atarashi and colleagues have discovered an assay that can identify prions in human cerebrospinal fluid. This assay could allow for diagnosis of disease in living humans.

Titanium-Based Biomaterials for Preventing Stress Shielding between Implant Devices and Bone

Abstract: β-type titanium alloys with low Young's modulus are required to inhibit bone atrophy and enhance bone remodeling for implants used to substitute failed hard tissue. At the same time, these titanium alloys are required to have high static and dynamic strength. On the other hand, metallic biomaterials with variable Young's modulus are required to satisfy the needs of both patients and surgeons, namely, low and high Young's moduli, respectively. In this paper, we have discussed effective methods to improve the static and dynamic strength while maintaining low Young's modulus for β-type titanium alloys used in biomedical applications. Then, the advantage of low Young's modulus of β-type titanium alloys in biomedical applications has been discussed from the perspective of inhibiting bone atrophy and enhancing bone remodeling. Further, we have discussed the development of β-type titanium alloys with a self-adjusting Young's modulus for use in removable implants.

The End of the Reionization Epoch Probed by Lyα Emitters at z = 6.5 in the Subaru Deep Field* **

Abstract: We report an extensive search for Lyα emitters (LAEs) at z = 6.5 in the Subaru Deep Field. Subsequent spectroscopy with Subaru and Keck identified eight more LAEs, giving a total of 17 spectroscopically confirmed LAEs at z = 6.5. Based on this spectroscopic sample of 17, complemented by a photometric sample of 58 LAEs, we have derived a more accurate Lyα luminosity function of LAEs at z = 6.5, which reveals an apparent deficit at the bright end of ∼0.75 mag fainter L*, compared with that observed at z = 5.7. The difference in the LAE luminosity functions between z = 5.7 and 6.5 is significant at the 3 σ level, which is reduced to 2 σ when cosmic variance is taken into account. This result may imply that the reionization of the universe has not been completed at z = 6.5. We found that the spatial distribution of LAEs at z = 6.5 was homogeneous over the field. We discuss the implications of these results for the reionization of the universe. © 2006. The American Astronomical Society. All rights reserved.

Experimental characterization of shear transformation zones for plastic flow of bulk metallic glasses

Abstract: We report experimental characterization of shear transformation zones (STZs) for plastic flow of bulk metallic glasses (BMGs) based on a newly developed cooperative shearing model [Johnson WL, Samwer K (2005) A universal criterion for plastic yielding of metallic glasses with a (T/Tg)2/3 temperature dependence. Phys Rev Lett 95: 195501]. The good agreement between experimental measurements and theoretical predictions in the STZ volumes provides compelling evidence that the plastic flow of metallic glasses occurs through cooperative shearing of unstable STZs activated by shear stresses. Moreover, the ductility of BMGs was found to intrinsically correlate with their STZ volumes. The experiments presented herein pave a way to gain a quantitative insight into the atomic-scale mechanisms of BMG mechanical behavior.