Institution
Tohoku University
Education•Sendai, Japan•
About: Tohoku University is a education organization based out in Sendai, Japan. It is known for research contribution in the topics: Magnetization & Alloy. The organization has 72116 authors who have published 170791 publications receiving 3941714 citations. The organization is also known as: Tōhoku daigaku.
Topics: Magnetization, Alloy, Catalysis, Population, Magnetic field
Papers published on a yearly basis
Papers
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TL;DR: It is found that carnosic acid activates the Keap1/Nrf2 transcriptional pathway by binding to specific KeAP1 cysteine residues, thus protecting neurons from oxidative stress and excitotoxicity, and suggesting that CA may represent a new type of neuroprotective electrophilic compound.
Abstract: Electrophilic compounds are a newly recognized class of redox-active neuroprotective compounds with electron deficient, electrophilic carbon centers that react with specific cysteine residues on targeted proteins via thiol (S-)alkylation. Although plants produce a variety of physiologically active electrophilic compounds, the detailed mechanism of action of these compounds remains unknown. Catechol ring-containing compounds have attracted attention because they become electrophilic quinones upon oxidation, although they are not themselves electrophilic. In this study, we focused on the neuroprotective effects of one such compound, carnosic acid (CA), found in the herb rosemary obtained from Rosmarinus officinalis. We found that CA activates the Keap1/Nrf2 transcriptional pathway by binding to specific Keap1 cysteine residues, thus protecting neurons from oxidative stress and excitotoxicity. In cerebrocortical cultures, CA-biotin accumulates in non-neuronal cells at low concentrations and in neurons at higher concentrations. We present evidence that both the neuronal and non-neuronal distribution of CA may contribute to its neuroprotective effect. Furthermore, CA translocates into the brain, increases the level of reduced glutathione in vivo, and protects the brain against middle cerebral artery ischemia/reperfusion, suggesting that CA may represent a new type of neuroprotective electrophilic compound.
360 citations
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TL;DR: Adjunctive ultrasonography increases sensitivity and detection rate of early cancers in asymptomatic women and reduces mortality in young women or women with dense breasts.
360 citations
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TL;DR: In this article, the authors proposed a method to determine the velocities of simulated molecules after a small time increment was derived from the Boltzmann equation, which was shown to give an exact solution of the Boltzman equation.
Abstract: The stochastic law that prescribes the velocities of simulated molecules after a small time increment was derived from the Boltzmann equation. The scheme to determine the velocity of a molecule after a small time increment is divided into three steps. The first step gives the collision probability of the molecule without specifying its collision partner. The second step gives a conditional probability distribution. If the molecule is accepted in the first step as a colliding molecule, its collision partner is sampled from this probability distribution. The last step gives a probability density from which the direction of the relative velocity after collision is sampled, and hence the step gives the post-collision velocity of the molecule. It is shown that the use of the present simulation scheme gives an exact solution of the Boltzmann equation.
360 citations
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TL;DR: The Japanese Association for Thoracic Surgery has conducted annual surveys of thoracic surgery throughout Japan since 1986 to determine the statistics regarding the number of procedures according to operative category.
Abstract: The Japanese Association for Thoracic Surgery has conducted annual surveys of thoracic surgery throughout Japan since 1986 to determine the statistics regarding the number of procedures according to operative category. Here, we have summarized the results from our annual survey of thoracic surgery performed during 2014.
359 citations
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TL;DR: In this paper, the laminar burning velocity of premixed methane-ammonia-air mixtures were studied experimentally and numerically over a wide range of equivalence ratios and ammonia concentrations.
359 citations
Authors
Showing all 72477 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Q. Trojanowski | 226 | 1467 | 213948 |
Aaron R. Folsom | 181 | 1118 | 134044 |
Marc G. Caron | 173 | 674 | 99802 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Kenji Watanabe | 167 | 2359 | 129337 |
Rodney S. Ruoff | 164 | 666 | 194902 |
Frederik Barkhof | 154 | 1449 | 104982 |
Takashi Taniguchi | 152 | 2141 | 110658 |
Yoshio Bando | 147 | 1234 | 80883 |
Thomas P. Russell | 141 | 1012 | 80055 |
Ali Khademhosseini | 140 | 887 | 76430 |
Marco Colonna | 139 | 512 | 71166 |
David H. Barlow | 133 | 786 | 72730 |
Lin Gu | 130 | 868 | 56157 |
Yoichiro Iwakura | 129 | 705 | 64041 |