University of Kiel

About: University of Kiel is a education organization based out in Kiel, Germany. It is known for research contribution in the topics: Population & Crystal structure. The organization has 27816 authors who have published 57114 publications receiving 2061802 citations. The organization is also known as: Christian Albrechts University & Christian-Albrechts-Universität zu Kiel.

Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.

Abstract: Most modern treatment protocols for acute lymphoblastic leukaemia (ALL) include the analysis of minimal residual disease (MRD). To ensure comparable MRD results between different MRD-polymerase chain reaction (PCR) laboratories, standardization and quality control are essential. The European Study Group on MRD detection in ALL (ESG-MRD-ALL), consisting of 30 MRD-PCR laboratories worldwide, has developed guidelines for the interpretation of real-time quantitative PCR-based MRD data. The application of these guidelines ensures identical interpretation of MRD data between different laboratories of the same MRD-based clinical protocol. Furthermore, the ESG-MRD-ALL guidelines will facilitate the comparison of MRD data obtained in different treatment protocols, including those with new drugs.

Automata logics, and infinite games: a guide to current research

Abstract: A central aim and ever-lasting dream of computer science is to put the development of hardware and software systems on a mathematical basis which is both firm and practical. Such a scientific foundation is needed especially for the construction of reactive programs, like communication protocols or control systems. For the construction and analysis of reactive systems an elegant and powerful theory has been developed based on automata theory, logical systems for the specification of nonterminating behavior, and infinite two-person games. The 19 chapters presented in this multi-author monograph give a consolidated overview of the research results achieved in the theory of automata, logics, and infinite games during the past 10 years. Special emphasis is placed on coherent style, complete coverage of all relevant topics, motivation, examples, justification of constructions, and exercises.

Identification of the familial cylindromatosis tumour-suppressor gene.

Abstract: Familial cylindromatosis is an autosomal dominant genetic predisposition to multiple tumours of the skin appendages. The susceptibility gene (CYLD) has previously been localized to chromosome 16q and has the genetic attributes of a tumour-suppressor gene (recessive oncogene). Here we have identified CYLD by detecting germline mutations in 21 cylindromatosis families and somatic mutations in 1 sporadic and 5 familial cylindromas. All mutations predict truncation or absence of the encoded protein. CYLD encodes three cytoskeletal-associated-protein-glycine-conserved (CAP-GLY) domains, which are found in proteins that coordinate the attachment of organelles to microtubules. CYLD also has sequence homology to the catalytic domain of ubiquitin carboxy-terminal hydrolases (UCH).

The structure and origin of magnetic clouds in the solar wind

Abstract: . Plasma and magnetic field data from the Helios 1/2 spacecraft have been used to investigate the structure of magnetic clouds (MCs) in the inner heliosphere. 46 MCs were identified in the Helios data for the period 1974–1981 between 0.3 and 1 AU. 85% of the MCs were associated with fast-forward interplanetary shock waves, supporting the close association between MCs and SMEs (solar mass ejections). Seven MCs were identified as direct consequences of Helios-directed SMEs, and the passage of MCs agreed with that of interplanetary plasma clouds (IPCs) identified as white-light brightness enhancements in the Helios photometer data. The total (plasma and magnetic field) pressure in MCs was higher and the plasma-β lower than in the surrounding solar wind. Minimum variance analysis (MVA) showed that MCs can best be described as large-scale quasi-cylindrical magnetic flux tubes. The axes of the flux tubes usually had a small inclination to the ecliptic plane, with their azimuthal direction close to the east-west direction. The large-scale flux tube model for MCs was validated by the analysis of multi-spacecraft observations. MCs were observed over a range of up to ~60° in solar longitude in the ecliptic having the same magnetic configuration. The Helios observations further showed that over-expansion is a common feature of MCs. From a combined study of Helios, Voyager and IMP data we found that the radial diameter of MCs increases between 0.3 and 4.2 AU proportional to the distance, R, from the Sun as R0.8 (R in AU). The density decrease inside MCs was found to be proportional to R–2.4, thus being stronger compared to the average solar wind. Four different magnetic configurations, as expected from the flux-tube concept, for MCs have been observed in situ by the Helios probes. MCs with left- and right-handed magnetic helicity occurred with about equal frequencies during 1974–1981, but surprisingly, the majority (74%) of the MCs had a south to north (SN) rotation of the magnetic field vector relative to the ecliptic. In contrast, an investigation of solar wind data obtained near Earth's orbit during 1984–1991 showed a preference for NS-clouds. A direct correlation was found between MCs and large quiescent filament disappearances (disparition brusques, DBs). The magnetic configurations of the filaments, as inferred from the orientation of the prominence axis, the polarity of the overlying field lines and the hemispheric helicity pattern observed for filaments, agreed well with the in situ observed magnetic structure of the associated MCs. The results support the model of MCs as large-scale expanding quasi-cylindrical magnetic flux tubes in the solar wind, most likely caused by SMEs associated with eruptions of large quiescent filaments. We suggest that the hemispheric dependence of the magnetic helicity structure observed for solar filaments can explain the preferred orientation of MCs in interplanetary space as well as their solar cycle behavior. However, the white-light features of SMEs and the measured volumes of their interplanetary counterparts suggest that MCs may not simply be just Hα-prominences, but that SMEs likely convect large-scale coronal loops overlying the prominence axis out of the solar atmosphere.