Institution
University of Kiel
Education•Kiel, Germany•
About: University of Kiel is a education organization based out in Kiel, Germany. It is known for research contribution in the topics: Population & Crystal structure. The organization has 27816 authors who have published 57114 publications receiving 2061802 citations. The organization is also known as: Christian Albrechts University & Christian-Albrechts-Universität zu Kiel.
Topics: Population, Crystal structure, Transplantation, Gene, Receptor
Papers published on a yearly basis
Papers
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Yale University1, Geneva College2, University of Tokyo3, University of Tübingen4, Goethe University Frankfurt5, University of Bonn6, Dresden University of Technology7, Utrecht University8, Helsinki University Central Hospital9, Tokai University10, University of Pécs11, Chiba University12, John Radcliffe Hospital13, University of Sheffield14, Royal Hallamshire Hospital15, Technische Universität München16, Erasmus University Medical Center17, University of Kiel18, French Institute of Health and Medical Research19, Catalan Institution for Research and Advanced Studies20, Pompeu Fabra University21, University Medical Center Groningen22, University of Helsinki23, Wellcome Trust Sanger Institute24
TL;DR: Two new loci showing strong evidence for association with intracranial aneurysms are identified and several putative risk genes play a role in cell-cycle progression, potentially affecting the proliferation and senescence of progenitor-cell populations that are responsible for vascular formation and repair.
Abstract: Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall; their hemorrhage commonly results in severe neurologic impairment and death. We report a second genome-wide association study with discovery and replication cohorts from Europe and Japan comprising 5,891 cases and 14,181 controls with approximately 832,000 genotyped and imputed SNPs across discovery cohorts. We identified three new loci showing strong evidence for association with intracranial aneurysms in the combined dataset, including intervals near RBBP8 on 18q11.2 (odds ratio (OR) = 1.22, P = 1.1 x 10(-12)), STARD13-KL on 13q13.1 (OR = 1.20, P = 2.5 x 10(-9)) and a gene-rich region on 10q24.32 (OR = 1.29, P = 1.2 x 10(-9)). We also confirmed prior associations near SOX17 (8q11.23-q12.1; OR = 1.28, P = 1.3 x 10(-12)) and CDKN2A-CDKN2B (9p21.3; OR = 1.31, P = 1.5 x 10(-22)). It is noteworthy that several putative risk genes play a role in cell-cycle progression, potentially affecting the proliferation and senescence of progenitor-cell populations that are responsible for vascular formation and repair.
294 citations
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TL;DR: In this article, the existence of zeros plays an important role, since it yields surjectivity results as well as fixed point theorems for operators S such that I-S is accretive.
Abstract: In the investigation of accretive operators in Banach spaces X, the existence of zeros plays an important role, since it yields surjectivity results as well as fixed point theorems for operators S such that I-S is accretive. Let D⊂X and T: D→X an operator such that the initial value problems
294 citations
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University of Bristol1, Hannover Medical School2, University of Copenhagen3, Erasmus University Rotterdam4, QIMR Berghofer Medical Research Institute5, Imperial College London6, Technische Universität München7, University of Kiel8, University of Pennsylvania9, University of Western Australia10, University of Basel11, University of Manchester12, VU University Amsterdam13, Karolinska Institutet14, Wellcome Trust Sanger Institute15, University of Geneva16, University of Oulu17, University of the East18, University of Washington19, University of Melbourne20, Ludwig Maximilian University of Munich21, University of Bonn22, Aarhus University23, Tartu University Hospital24, Statens Serum Institut25, University of Iowa26, Children's Hospital of Philadelphia27, King's College London28, Telethon Institute for Child Health Research29, Children's Medical Research Institute30, Swiss Tropical and Public Health Institute31, Norwegian Institute of Public Health32, Manchester Academic Health Science Centre33, Utrecht University34, Copenhagen University Hospital35, Karolinska University Hospital36, Sahlgrenska University Hospital37, Ontario Institute for Cancer Research38, St George's, University of London39, Medical Research Council40
TL;DR: A genome-wide association meta-analysis of affected individuals and controls and the ten most strongly associated new susceptibility loci examined underline the importance of both epidermal barrier function and immune dysregulation in atopic dermatitis pathogenesis.
Abstract: Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10(-13)) and rs2164983 near ACTL9 (OR = 1.16, P = 7.1 × 10(-9)), both of which are near genes that have been implicated in epidermal proliferation and differentiation, as well as rs2897442 in KIF3A within the cytokine cluster at 5q31.1 (OR = 1.11, P = 3.8 × 10(-8)). We also replicated association with the FLG locus and with two recently identified association signals at 11q13.5 (rs7927894; P = 0.008) and 20q13.33 (rs6010620; P = 0.002). Our results underline the importance of both epidermal barrier function and immune dysregulation in atopic dermatitis pathogenesis.
294 citations
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TL;DR: The results provide a new insight on the regulation of gene expression under low-oxygen conditions and show that lighting plays an important regulatory role and is intertwined with hypoxia conditions; both stimuli may act collaboratively to regulate the hypoxic response.
Abstract: Arabidopsis (Arabidopsis thaliana) RAP2.2 (At3g14230) is an APETALA2/ethylene response factor-type transcription factor that belongs to the same subfamily as the rice (Oryza sativa) submergence tolerance gene SUB1A. RAP2.2 is expressed at constitutively high levels in the roots and at lower levels in the shoots, where it is induced by darkness. Effector studies and analysis of ethylene signal transduction mutants indicate that RAP2.2 is induced in shoots by ethylene and functions in an ethylene-controlled signal transduction pathway. Overexpression of RAP2.2 resulted in improved plant survival under hypoxia (low-oxygen) stress, whereas lines containing T-DNA knockouts of the gene had poorer survival rates than the wild type. This indicates that RAP2.2 is important in a plant's ability to resist hypoxia stress. Observation of the expression pattern of 32 low-oxygen and ethylene-associated genes showed that RAP2.2 affects only part of the low-oxygen response, particularly the induction of genes encoding sugar metabolism and fermentation pathway enzymes, as well as ethylene biosynthesis genes. Our results provide a new insight on the regulation of gene expression under low-oxygen conditions. Lighting plays an important regulatory role and is intertwined with hypoxia conditions; both stimuli may act collaboratively to regulate the hypoxic response.
294 citations
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University of Paris1, Sorbonne2, Ludwig Maximilian University of Munich3, The Catholic University of America4, University of Ulm5, University of Cologne6, Lyon College7, Institut Gustave Roussy8, Paracelsus Private Medical University of Salzburg9, University of Tübingen10, University of Kiel11, French Institute of Health and Medical Research12
TL;DR: Investigating whether the introduction of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation (ASCT) improves outcome found it should be considered standard of care in patients aged 65 years or younger with mantle cell lymphoma.
293 citations
Authors
Showing all 28103 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stefan Schreiber | 178 | 1233 | 138528 |
Jun Wang | 166 | 1093 | 141621 |
William J. Sandborn | 162 | 1317 | 108564 |
Jens Nielsen | 149 | 1752 | 104005 |
Tak W. Mak | 148 | 807 | 94871 |
Annette Peters | 138 | 1114 | 101640 |
Severine Vermeire | 134 | 1086 | 76352 |
Peter M. Rothwell | 134 | 779 | 67382 |
Dusan Bruncko | 132 | 1042 | 84709 |
Gideon Bella | 129 | 1301 | 87905 |
Dirk Schadendorf | 127 | 1017 | 105777 |
Neal L. Benowitz | 126 | 792 | 60658 |
Thomas Schwarz | 123 | 701 | 54560 |
Meletios A. Dimopoulos | 122 | 1371 | 71871 |
Christian Weber | 122 | 776 | 53842 |