Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
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Worth the Weight: Using Inverse Probability Weighted Cox Models in AIDS Research
TL;DR: This article presents a method that uses inverse probability (IP) weights to estimate the effect of a baseline exposure on a time-to-event outcome, using an example that estimates theeffect of injection drug use on time until AIDS or death among HIV-infected women.
Journal ArticleDOI
Nodal Status, Number of Lymph Nodes Examined, and Lymph Node Ratio: What Defines Prognosis after Resection of Colon Adenocarcinoma?
Ana Gleisner,Harveshp Mogal,Rebecca M. Dodson,Jon Efron,Susan L. Gearhart,Elizabeth C. Wick,Anne O. Lidor,Joseph M. Herman,Timothy M. Pawlik +8 more
TL;DR: The combined effect of NMLN and TNLE is complex and is not appropriately represented by the LNR, which may be an alternative to the N stage for prognostication of patients with colon cancer because it accounts for differences in nodal samples.
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Modeling the Growth Boundary of Listeria monocytogenes in Ready-to-Eat Cooked Meat Products as a Function of the Product Salt, Moisture, Potassium Lactate, and Sodium Diacetate Concentrations
TL;DR: The model was used to show the boundary between growth and no-growth conditions at 4 degrees C using contour plots of time to growth, and predicted well, particularly for cured products, where it will be useful for establishing conditions that prevent the growth of L. monocytogenes.
Journal ArticleDOI
The Women's international study of long-duration oestrogen after menopause (WISDOM): a randomised controlled trial
TL;DR: The trial was prematurely closed during recruitment following publication of early results from the Women's Health Initiative, and the WISDOM experience leads to some simple messages that funders and investigators should make every effort to develop international collaboration with joint funding.
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Methods of competing risks analysis of end-stage renal disease and mortality among people with diabetes
TL;DR: This study applied cause-specific and subdistribution hazards models to a diabetes dataset with two competing risks to measure the relative effects of covariates and cumulative incidence functions and revealed the cumulative incidence curve of the risk of ESRD by the cause- specific hazards model was revealed to be higher than the curves generated by the subdist distribution hazards model.
References
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Journal ArticleDOI
Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
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Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
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Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.