Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
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Prognostic factors in patients with advanced non-small cell lung cancer: data from the phase III FLEX study.
Robert Pirker,José Rodrigues Pereira,A. Szczesna,J. von Pawel,Maciej Krzakowski,Rodryg Ramlau,Ihor Vynnychenko,Kwan Park,Wilfried Eberhardt,F. De Marinis,S. Heeger,Thomas Goddemeier,Kenneth J. O'Byrne,Ulrich Gatzemeier +13 more
TL;DR: In patients with advanced NSCLC enrolled in the FLEX study, and consistent with previous analyses, particular patient and disease characteristics at baseline were shown to be independent factors of prognostic value.
Journal ArticleDOI
How long do direct restorations placed within the general dental services in England and Wales survive
F.J.T. Burke,P.S.K. Lucarotti +1 more
TL;DR: Small amalgam restorations have longer survival times before re-intervention than large amalgam Restorations such as MOD and Composite and glass ionomers perform less well than amalgamRestorations placed by older dentists and restoration placed in older patients have shorter time to re-Intervention.
Journal ArticleDOI
Comprehensive evaluation of published gene expression prognostic signatures for biomarker-based lung cancer clinical studies
Hao Tang,Siling Wang,Guanghua Xiao,Joan H. Schiller,Vassiliki A. Papadimitrakopoulou,John D. Minna,I. I. Wistuba,I. I. Wistuba,Yang Xie +8 more
TL;DR: The goal of this study was to identify the most promising mRNA prognostic signatures in NSCLC for further prospective clinical validation and identify a set of mRNA expression prognostic signs appropriate for further validation in prospective clinical studies.
Journal ArticleDOI
Randomized trial of a comprehensive asthma education program after an emergency department visit.
TL;DR: Delivery of a comprehensive AE program after an ED visit was ineffective in adult patients; however, it may be effective in children.
Journal ArticleDOI
Human exposure assessment of different arsenic species in household water sources in a high risk arsenic area.
TL;DR: This exposure estimate has indicated that 63% of rural residents exceeded the World Health Organization's provisional tolerable daily intake (PTDI) of 2.1μgkg-1day-1 body weight.
References
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Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.