Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
Citations
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The Kumaraswamy-Log-Logistic Distribution
TL;DR: Based on the log-logistic and Kumaraswamy distributions, this paper introduced the called KumarASwamy-log-logistics distribution, which contains several important distributions discussed in the literature as sub-models such as the loglogistic, exponentiated log- logistic and Burr XII distributions, among several others.
Journal ArticleDOI
A phase II study of metronomic oral vinorelbine administered in the second line and beyond in non-small cell lung cancer (NSCLC): a phase II study of the Hellenic Oncology Research Group
Emmanouil Kontopodis,Dora Hatzidaki,Ioannis Varthalitis,Nikolaos Kentepozidis,Stylianos Giassas,Nikolaos Pantazopoulos,Nikolaos Vardakis,Maria Rovithi,Vassilis Georgoulias,Sofia Agelaki +9 more
TL;DR: The administration of metronomic oral vinorelbine is feasible and results in acceptable clinical efficacy associated with manageable toxicity in a population consisting mostly of heavily pre-treated NSCLC patients.
Journal ArticleDOI
The cost-effectiveness of an early interventional strategy in non-ST-elevation acute coronary syndrome based on the RITA 3 trial
Martin Henriksson,David Epstein,Stephen Palmer,Mark Sculpher,Tim Clayton,Stuart J. Pocock,Robert A. Henderson,Martin Buxton,Keith A.A. Fox +8 more
TL;DR: An early interventional strategy in patients presenting with NSTE-ACS is likely to be considered cost-effective for patients at high and intermediate risk, but this is less likely to been the case for patientsat low risk.
Journal ArticleDOI
Acute Lead Toxicosis in Mourning Doves
John Schulz,Joshua J. Millspaugh,A. J. Bermudez,Xiaoming Gao,Thomas W. Bonnot,Lisa G. Britt,Mark Paine +6 more
TL;DR: The results support an acute lead toxicosis hypothesis in mourning doves and recommend that management agencies initiate development of a long-term strategic plan aimed at implementing a nontoxic shot regulation for mourning dove hunting.
Journal ArticleDOI
Lapatinib versus lapatinib plus capecitabine as second-line treatment in human epidermal growth factor receptor 2-amplified metastatic gastro-oesophageal cancer: a randomised phase II trial of the Arbeitsgemeinschaft Internistische Onkologie.
Sylvie Lorenzen,Jorge Riera Knorrenschild,G.M. Haag,Michael Pohl,Peter C. Thuss-Patience,Florian Bassermann,Ulrike Helbig,Florian Weißinger,Elisabeth Schnoy,Klaus Becker,Gertraud Stocker,Josef Rüschoff,Andreas Eisenmenger,Irini Karapanagiotou-Schenkel,Florian Lordick +14 more
TL;DR: Lapatinib showed insufficient activity in HER2-amplified pretreated advanced GC and the safety profile of LAP or LAP+CAP was as expected with some more toxicity in the combination arm and other adverse events were mostly similar between the groups.
References
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Journal ArticleDOI
Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.