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4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
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Long-term Results of Molteno Implant Insertion in Cases of Neovascular Glaucoma
TL;DR: The insertion of Molteno implants for neovascular glaucoma maintained or improved vision in 39% of eyes, whereas 12% were eventually enucleated (all of which initially had visual acuity <20/1200), the outcome depended mainly on progression of the underlying vascular disease.
Journal ArticleDOI
Contraceptive effectiveness of a polyurethane condom and a latex condom: a randomized controlled trial.
TL;DR: The polyurethane condom was not shown to be as effective as the latex comparator condom for pregnancy prevention, however, the risk of pregnancy in the polyUREthane group falls in the range of other barrier methods.
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Influence of induced plant defenses in cotton and tomato on the efficacy of baculoviruses on noctuid larvae
TL;DR: For both plant species, peroxidase (POD) and phenolic levels were predictive of larval mortality caused by baculoviruses, which implies that viral efficacy is predictable only if total chemical content of the plants is specified.
Journal ArticleDOI
Beta-catenin in soft tissue sarcomas: expression is related to proliferative activity in high-grade sarcomas.
Cornelius Kuhnen,Peter Herter,Oliver Müller,T. Muehlberger,Larissa Krause,Heinz H. Homann,Hans U. Steinau,Klaus-Michael Müller +7 more
TL;DR: Besides its role in cell adhesion, β-catenin exerts a function as an oncoprotein in sarcomas with intracytoplasmic and nuclear localization with binding to nuclear DNA and a previously discussed stimulation of cell proliferation caused by an increased β- catenin level can be postulated for high-grade soft tissue sarcoma in correlation with the rate of proliferation.
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Time to relapse after 6 and 12 months' treatment of generalized anxiety disorder with venlafaxine extended release.
TL;DR: Preliminary data demonstrate that improved patients who relapse while off their antianxiety medication after at least 6 months of treatment will again most likely respond to a second course of treatment with the same medication.
References
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Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.