Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
Citations
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Survival among COPD patients using fluticasone/salmeterol in combination versus other inhaled steroids and bronchodilators alone.
Douglas W. Mapel,Leila S. Nelson,Eva Lydick,Joan B. Soriano,Marianne Ulcickas Yood,Kourtney J. Davis +5 more
TL;DR: Treatment with FSI or another ICS with or without LABA is associated with improved survival in COPD, and the treatment benefit is reproducible and is robust to application of a number of different analysis techniques designed to adjust for differences in confounding variables and for bias by indication.
Journal ArticleDOI
The incidence and prevalence of orphanhood associated with parental HIV infection: a population-based study in Rakai, Uganda.
Fredrick Makumbi,Ronald H. Gray,David Serwadda,Fred Nalugoda,Mohamed Kiddugavu,Nelson K. Sewankambo,Fred Wabwire-Mangen,Maria J. Wawer +7 more
TL;DR: Parental HIV infection markedly increased the incidence of orphanhood, especially among younger children and the children of younger mothers, and in a rural population with a 14.8% adult HIV prevalence.
Journal ArticleDOI
Predictive factors of antiproliferative activity of octreotide LAR as first-line therapy for advanced neuroendocrine tumours.
Faidon-Marios Laskaratos,Martin Walker,Keval Naik,Emmanouil Maragkoudakis,Nikolaos Oikonomopoulos,Lee Alexander Grant,Tim Meyer,Tim Meyer,Martyn Caplin,Christos Toumpanakis +9 more
TL;DR: The duration of the antiproliferative effect of octreotide LAR seems to be longer than previously reported and several predictors of response in a large cohort of patients with NETs on somatostatin analogue therapy are identified.
Journal ArticleDOI
Improved Survival Outcomes in Cancer Patients with Hereditary Hemorrhagic Telangiectasia
Christine W. Duarte,Kimberly Murray,F. Lee Lucas,Kathleen M. Fairfield,Heather Miller,Peter C. Brooks,Calvin P.H. Vary +6 more
TL;DR: The hypothesis that systemically educed endoglin expression is associated with improved survival outcome in multiple cancers is supported, and it is suggested that anti-endoglin antibody therapy may have broad-based application.
Journal ArticleDOI
A new simplified immediate prognostic risk score for patients with acute myocardial infarction.
Brent A. Williams,R S Wright,Joseph G. Murphy,Emmanouil S. Brilakis,Guy S. Reeder,Allan S. Jaffe +5 more
TL;DR: The present results suggest that even amidst changing patient profiles, treatment, and disease definitions, the Mayo model is useful for 30 day risk assessment following AMI.
References
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Journal ArticleDOI
Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.