Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
Citations
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Long-term mortality after a first episode of status epilepticus.
G. Logroscino,D. C. Hesdorffer,D. C. Hesdorffer,Gregory D. Cascino,John F. Annegers,John F. Annegers,Emilia Bagiella,W. A. Hauser,W. A. Hauser +8 more
TL;DR: The long-term mortality rate was threefold that of the general population over the same time period and was worse for those with myoclonic SE, for those who presented with SE lasting more than 24 hours, and for Those with acute symptomatic SE.
Journal ArticleDOI
Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the cambodian–thai border
Alisa P. Alker,Pharath Lim,Rithy Sem,Naman K. Shah,Poravuth Yi,Denis Mey Bouth,Reiko Tsuyuoka,Jason D. Maguire,Thierry Fandeur,Frédéric Ariey,Chansuda Wongsrichanalai,Steven R. Meshnick +11 more
TL;DR: Artemisinin combination therapies have recently been adopted as first-line therapy for Plasmodium falciparum infections in most malaria-endemic countries and should be evaluated further as a surveillance tool for artesunate-mefloquine resistance in Cambodia.
Journal ArticleDOI
Survival after AIDS diagnosis in adolescents and adults during the treatment era, United States, 1984-1997.
TL;DR: While AIDS incidence is declining, improved survival times present a growing public health challenge as the number of persons living with chronic human immunodeficiency virus disease/AIDS increases.
Journal ArticleDOI
Highly active antiretroviral therapy and survival in HIV-infected injection drug users.
Evan Wood,Robert S. Hogg,Viviane D. Lima,Thomas Kerr,Benita Yip,Brandon D.L. Marshall,Julio S. G. Montaner +6 more
TL;DR: In this study population, injection drug use was not associated with decreased survival among HIV-infected patients initiating HAART, and the hazard ratio of mortality was similar between IDUs and non-IDUs.
Journal ArticleDOI
Results of the EICESS-92 Study: Two Randomized Trials of Ewing's Sarcoma Treatment—Cyclophosphamide Compared With Ifosfamide in Standard-Risk Patients and Assessment of Benefit of Etoposide Added to Standard Treatment in High-Risk Patients
Michael Paulussen,Alan W. Craft,Ian Lewis,Allan Hackshaw,Carolyn Douglas,Jürgen Dunst,Andreas Schuck,Winfried Winkelmann,Gabriele Köhler,Christopher Poremba,Andreas Zoubek,Ruth Ladenstein,Henk van den Berg,Andrea Hunold,A Cassoni,D. Spooner,Robert J. Grimer,Jeremy Whelan,Anne McTiernan,Herbert Jürgens +19 more
TL;DR: Cyclophosphamide seemed to have a similar effect on EFS and OS as ifosfamide in SR patients but was associated with increased toxicity and in HR patients, the addition of etoposide seemed to be beneficial.
References
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Journal ArticleDOI
Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.