Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
Citations
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Getting more out of survival data by using the hazard function.
Kenneth R. Hess,Victor A. Levin +1 more
TL;DR: The hazard function tracks the instantaneous failure rate over time among the surviving patients and can be readily estimated with available software and illustrated how these estimates can be used in conjunction with estimates of the survival function to glean clinically relevant information from survival data.
Journal ArticleDOI
Is surveillance imaging effective for detecting surgically treatable recurrences in patients with melanoma? A comparative analysis of stage-specific surveillance strategies.
Natasha M. Rueth,Yan Xing,Yi Ju Chiang,Kate D. Cromwell,Merrick I. Ross,Jeffrey E. Lee,Jeffrey E. Gershenwald,Richard E. Royal,Janice N. Cormier +8 more
TL;DR: The effectiveness of routine surveillance imaging for detecting treatable melanoma recurrences is limited and even in patients with stage III disease, only minimal gains in life expectancy were achieved.
Journal ArticleDOI
A comparison of methods for fixed effects meta-analysis of individual patient data with time to event outcomes:
TL;DR: Comparisons of commonly used methods for fixed effects meta-analysis of individual patient time-to-event data suggest that under normal conditions all three methods provide similar results.
Journal ArticleDOI
Prognostic study of continuous variables (white blood cell count, peripheral blast cell count, haemoglobin level, platelet count and age) in childhood acute lymphoblastic leukaemia. Analysis Of a population of 1545 children treated by the French Acute Lymphoblastic Leukaemia Group (FRALLE).
Jean Donadieu,Marie-Françoise Auclerc,André Baruchel,Y Perel,Pierre Bordigoni,Judith Landman-Parker,Thierry Leblanc,Guy Cornu,Danièle Sommelet,Guy Leverger,G. Schaison,Catherine Hill +11 more
TL;DR: Variations in the relative risk of relapse or death as a function of continuous prognostic variables in childhood ALL are analyzed and consensus cutpoints must be defined if one wants to avoid the Will Rogers phenomenon.
Journal Article
Hip fracture evaluation with alternatives of total hip arthroplasty versus hemiarthroplasty (HEALTH): Protocol for a multicentre randomised trial
Mohit Bhandari,Philip J. Devereaux,Thomas A. Einhorn,Lehana Thabane,Emil H. Schemitsch,Kenneth J. Koval,Frede Frihagen,Rudolf W. Poolman,Kevin Tetsworth,Ernesto Guerra-Farfán,Kim Madden,Sheila Sprague,Gordon H. Guyatt +12 more
TL;DR: The HEALTH trial as discussed by the authors compared outcomes following total hip arthroplasty (THA) versus hemiarthroplastic surgery (HA) in patients with displaced femoral neck fractures.
References
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Journal ArticleDOI
Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.