Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
Citations
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Time to default in credit scoring using survival analysis: a benchmark study
TL;DR: It is found that spline-based methods and the single event mixture cure model perform well in the credit risk context.
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Response as a predictor of survival in patients with recurrent glioblastoma treated with bevacizumab
Michael D. Prados,Timothy F. Cloughesy,Meghna Samant,Liang Fang,Patrick Y. Wen,Tom Mikkelsen,David Schiff,Lauren E. Abrey,W. K. Alfred Yung,Nina Paleologos,Martin K. Nicholas,Randy L. Jensen,James J. Vredenburgh,Asha Das,Henry S. Friedman +14 more
TL;DR: A landmark analysis was performed to evaluate the association between OR and survival at 9, 18, and 26 weeks for 167 patients with recurrent GBM who participated in BRAIN, a phase II trial that evaluated efficacy of bevacizumab alone or in combination with irinotecan.
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In Vivo Treatment Sensitivity Testing With Positron Emission Tomography/Computed Tomography After One Cycle of Chemotherapy for Hodgkin Lymphoma
Martin Hutchings,L. Kostakoglu,Jan Maciej Zaucha,Bogdan Małkowski,Alberto Biggi,Iwona Danielewicz,Annika Loft,Lena Specht,Dominick Lamonica,Myron S. Czuczman,C. Nanni,Pier Luigi Zinzani,Louis F. Diehl,Richard Stern,Morton Coleman +14 more
TL;DR: PET after one cycle of chemotherapy is highly prognostic in HL, and in the absence of precise pretherapeutic predictive markers, PET1 is the best method for response-adapted strategies designed to select patients for less intensive treatment.
Journal ArticleDOI
Prognostic factors for duration of sick leave due to low-back pain in dutch health care professionals.
Ivan A. Steenstra,Fieke S. Koopman,Dirk L. Knol,Eric Kat,Paulien M Bongers,Henrica C.W. de Vet,Willem van Mechelen +6 more
TL;DR: Poor prognosis for duration of Sick leave can be identified by means of a simple questionnaire administered on the first day of sick leave.
Journal ArticleDOI
A Time to Event Tutorial for Pharmacometricians
TL;DR: Hazards and how doses can be linked to events predicted from hazard functions are explained and described in this tutorial.
References
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Journal ArticleDOI
Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.