Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
Citations
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Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer.
Yangsik Jeong,Yangsik Jeong,Yang Xie,Guanghua Xiao,Carmen Behrens,Luc Girard,Ignacio I. Wistuba,John D. Minna,David J. Mangelsdorf +8 more
TL;DR: It is shown that nuclear receptor expression is strongly associated with clinical outcomes of lung cancer patients, and this expression profile is a potential prognostic signature for lung cancer patient survival time, particularly for individuals with early stage disease.
Journal ArticleDOI
Haloperidol enhances latent inhibition in visual tasks in healthy people.
TL;DR: A comparison of the results from the studies at the two different doses suggests a dose dependence of haloperidol’s effects on latent inhibition that parallels results from animal work.
Journal ArticleDOI
Eight-year study on conventional glass ionomer and amalgam restorations in primary teeth.
TL;DR: Owing to the high frequency of failures of the conventional glass ionomer and amalgam restorations, it was concluded that they are not an appropriate, universal alternative to amalgam for restoration in primary teeth, although they reduce caries progression and the need for operative treatment of adjacent surfaces.
Journal ArticleDOI
Selective modulation of task performance by octopamine in honey bee ( Apis mellifera ) division of labour
TL;DR: Octopamine treatment enhanced the foraging response to brood pheromone but not the cell capping response, a component of brood care, demonstrating a relatively specific form of neuromodulation by octopamine in the regulation of division of labour in honey bee colonies.
Journal ArticleDOI
Apolipoprotein E e4 allele is associated with more rapid motor decline in older persons.
Aron S. Buchman,Patricia A. Boyle,Robert S. Wilson,Todd Beck,Jeremiah F. Kelly,David A. Bennett +5 more
TL;DR: It is suggested that the presence of ϵ4 allele is a risk factor for more rapid motor decline in the elderly and was for the most part explained by the association between ϵ 4 allele and change in muscle strength.
References
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Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.