Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
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Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.
References
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Proceedings ArticleDOI
Cohort Comparison of Event Sequences with Balanced Integration of Visual Analytics and Statistics
TL;DR: A taxonomy of metrics for comparing cohorts of temporal event sequences, showing that the problem-space is bounded is presented, and a visual analytics tool, CoCo, which implements balanced integration of automated statistics with an intelligent user interface to guide users to significant, distinguishing features between the cohorts is presented.
Journal ArticleDOI
Prognostic Relevance of Clinical and Biological Risk Factors in Childhood Medulloblastoma: Results of Patients Treated in the Prospective Multicenter Trial HIT'91
Stefan Rutkowski,André O. von Bueren,Katja von Hoff,Wolfgang Hartmann,Tarek Shalaby,Frank Deinlein,Monika Warmuth-Metz,Niels Soerensen,Angela Emser,Udo Bode,Uwe Mittler,Christian Urban,Martin Benesch,Rolf D. Kortmann,Paul G. Schlegel,Joachim Kuehl,Torsten Pietsch,Michael A. Grotzer +17 more
TL;DR: Whereas the collection of fresh-frozen tumor samples remains a major challenge in large clinical trials, routinely processed paraffin-embedded tissue samples can be used to quantitate the prognostic biological markers trkC and c-myc and may lead to improved stratification of treatment for children with medulloblastoma.
Journal Article
Body Size and Composition and Risk of Postmenopausal Breast Cancer
TL;DR: Given that elements of body size and composition are positively associated with breast cancer risk, although not until 15 or more years postmenopause, it is possible that women could reduce risk by maintaining ideal body weight after menopause.
Journal ArticleDOI
Reuse of nevirapine in exposed HIV-infected children after protease inhibitor-based viral suppression: a randomized controlled trial.
Ashraf Coovadia,Elaine J. Abrams,Renate Stehlau,Tammy Meyers,Leigh Martens,Gayle G. Sherman,Gillian Hunt,Chih-Chi Hu,Wei-Yann Tsai,Lynn Morris,Louise Kuhn +10 more
TL;DR: In this article, a randomized trial was conducted to test whether nevirapine-exposed infants who initially achieved viral suppression with PI-based therapy can maintain viral suppression when switched to nevapine based therapy.
Journal ArticleDOI
Incidence of Remission in Adults With Type 2 Diabetes: The Diabetes & Aging Study
TL;DR: In community settings, remission of type 2 diabetes does occur without bariatric surgery, but it is very rare, and variables associated with remission are identified.