Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
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Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.
References
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Journal ArticleDOI
DegreeCox – a network-based regularization method for survival analysis
André Veríssimo,Arlindo L. Oliveira,Arlindo L. Oliveira,Marie-France Sagot,Marie-France Sagot,Susana Vinga +5 more
TL;DR: DegreeCox is a method that applies network-based regularizers to infer Cox proportional hazard models, when the features are genes and the outcome is patient survival, and is proposed to use network centrality measures to constrain the model in terms of significant genes.
Journal ArticleDOI
Glycemia, Insulin Resistance, Insulin Secretion, and Risk of Depressive Symptoms in Middle Age
Tasnime N. Akbaraly,Meena Kumari,Jenny Head,Karen Ritchie,Marie-Laure Ancelin,Adam G. Tabak,Eric J. Brunner,Isabelle Chaudieu,Michael Marmot,Jane E. Ferrie,Martin J. Shipley,Mika Kivimäki +11 more
TL;DR: Low insulin secretion appears to be a risk factor for DepS in middle-aged women, although further work is required to confirm this finding.
The application of Firth's procedure to Cox and logistic regression
TL;DR: In this paper, the authors present the results of an extensive simulation study exploring the properties of Firth's procedure in logistic and Cox regression, and the empirical bias of parameter estimates obtained by Firth-type parameter estimates is compared to that resulting from ordinary maximum likelihood estimation in logistically and Cox regressions.
Journal ArticleDOI
The Statistical Analysis of Interval-Censored Failure Time Data with Applications
TL;DR: This paper explores the statistical analysis of interval-censored failure time data with applications and parametric and nonparametric methods of analysis are carried out.
Journal ArticleDOI
Prognosis of patients with whiplash-associated disorders consulting physiotherapy: development of a predictive model for recovery.
Tony Bohman,Pierre Côté,Pierre Côté,Eleanor Boyle,Eleanor Boyle,Eleanor Boyle,J. David Cassidy,J. David Cassidy,J. David Cassidy,Linda J. Carroll,Eva Skillgate +10 more
TL;DR: A model predicting recovery from WAD, in a cohort of patients who consulted physical therapists, has adequate predictive ability, but to be fully incorporated in clinical practice the model needs to be validated in other populations and tested in clinical settings.