Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
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Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.
References
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Journal ArticleDOI
Estimating and comparing reduction in HIV-1 RNA in clinical trials using methods for interval censored data.
TL;DR: This work suggests using nonparametric and parametric methods introduced for interval-censored data to analyze HIV-1 RNA reduction data, and finds that the log10 transformation of the HIV- 1 RNA reduction was not appropriate in the data.
Dissertation
Can routinely collected primary care data determine the prevalence of chronic kidney disease and predict clinical events in patients with stages 3 of the disease
TL;DR: Many practices mis-label CKD which impacts upon management and some predictors of mortality and morbidity is different to previous reports and this requires further investigation.
Journal ArticleDOI
Is a biomarker-based diagnostic strategy for invasive aspergillosis cost effective in high-risk haematology patients?
Nenad Macesic,C. O. Morrissey,Danny Liew,Megan Bohensky,Sharon C.-A. Chen,Nicole Gilroy,Sam Milliken,Jeff Szer,Monica A. Slavin +8 more
TL;DR: BDS is not cost‐sparing but is cost‐effective if a survival benefit is maintained over several years, and an individualized institutional approach to diagnostic strategies may maximize utility and cost‐effectiveness.
Journal ArticleDOI
Measuring differential treatment benefit across marker specific subgroups: the choice of outcome scale
Jaya M. Satagopan,Alexia Iasonos +1 more
TL;DR: Investigation of interaction contrasts under three scales of interaction for evaluating a predictive biomarker using reconstructed data from a published melanoma study shows that it can have a non-zero interaction on survival or logarithm of survival probability scales even when there is no interaction on the logariths of hazard ratio scale.
Proceedings ArticleDOI
Assessment of Explanatory Variables on the Failure Rate of Circuit Breakers Using the Proportional Hazard Model
TL;DR: In this paper, the authors used the proportional hazard model to understand and quantify the impact of explanatory variables on the failure rate of circuit breakers (CB) and found that PM has a positive impact, the number of operations within the last year a negative impact, and age has a small but negative impact on failure rate.