Journal ArticleDOI
4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
Citations
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Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.
References
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Journal ArticleDOI
Competing risks, left truncation and late entry effect in A-bomb survivors cohort.
TL;DR: In this paper, a Weibull distribution was used to determine the possible existence of a late entry effect in Hiroshima A-bomb survivors living in Hiroshima Prefecture since 1968, where the survival experience of the late entrants to the cohort is significantly different from the registered population in 1968.
Journal ArticleDOI
Single-Cell Force Spectroscopy of Interaction of Lipopolysaccharides from Yersinia pseudotuberculosis and Yersinia pestis with J774 Macrophage Membrane Using Optical Tweezers
TL;DR: In this article, the role of lipopolysaccharides (LPS) from outer bacterial membrane at the initial state of bacterium adhesion to a host cell membrane was investigated.
Journal ArticleDOI
Confidence Intervals Estimation for Survival Function in Log-Logistic Distribution and Proportional Odds Regression Based on Censored Survival Time Data
Kamil Alakuş,Necati Alp Erilli +1 more
TL;DR: In this study, a confidence interval is formed on confidence interval for log-logistic distribution survival function for any values of the time provided that the survival times have a log- logistic distributed random variable.
Dissertation
Temporal uncertainty in cost-effectiveness decision models:methods to address the uncertainties that arise when the appropriate analysis time horizon exceeds the evidence time horizon in cost-effectiveness decision models as applied to healthcare interventions
TL;DR: This thesis represents a contribution to the development of methods to aid decision making in healthcare by recommending that temporal uncertainty be characterised by a single uncertain ‘temporal’ parameter and incorporated into a probabilistic analysis in order to provide a true estimate of expected cost-effectiveness and to estimate the value of obtaining information that would lessen temporal uncertainty.
Journal ArticleDOI
Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis.
TL;DR: Analysis of public genomic data for HPV-negative oral cavity squamous cell carcinoma shows promise in identifying biomarkers that may allow clinicians to make more accurate survival predictions, and spectrin is a strong candidate for further biomarker testing.